Knuf Markus, Zepp Fred, Meyer Claudius, Grzegowski Edith, Wolter Joanne, Riffelmann Marion, Wirsing von König Carl Heinz
Department of Pediatrics, Johannes Gutenberg University of Mainz, Germany.
Vaccine. 2006 Mar 15;24(12):2043-8. doi: 10.1016/j.vaccine.2005.11.024. Epub 2005 Nov 28.
German adolescents (n=123) without previous pertussis vaccination, no history of pertussis and low IgG-anti-pertussis-toxin (PT) levels received one dose of the Tdap vaccine Boostrix. Blood samples were taken before, and 5-12 days and 29-49 days after vaccination. IgG- and IgA-anti-PT, IgG- and IgA-anti filamentous hemagglutinin, IgG-anti-pertactin, IgG-anti-tetanus-toxin, and IgG-anti-diphtheria-toxin were measured by ELISA. 88.6% of subjects had an immune response to PT, and all vaccinees had an immune response to at least one pertussis antigen 29-49 days after vaccination. IgA-anti-PT and IgA-anti-FHA responses were found in 43 and 81% of subjects, respectively. This study shows that in unvaccinated German adolescents pertussis immunity can be achieved by a single dose of Tdap.
123名未曾接种过百日咳疫苗、无百日咳病史且抗百日咳毒素（PT）的IgG水平较低的德国青少年接种了一剂吸附无细胞百白破疫苗（Tdap）“保适博”。在接种前、接种后5 - 12天以及29 - 49天采集血样。通过酶联免疫吸附测定法（ELISA）检测抗PT的IgG和IgA、抗丝状血凝素的IgG和IgA、抗百日咳杆菌黏附素的IgG、抗破伤风毒素的IgG以及抗白喉毒素的IgG。88.6%的受试者对PT产生了免疫反应，并且所有接种者在接种后29 - 49天对至少一种百日咳抗原产生了免疫反应。分别在43%和81%的受试者中发现了抗PT的IgA和抗丝状血凝素（FHA）的IgA反应。这项研究表明，在未接种疫苗的德国青少年中，一剂Tdap疫苗可实现百日咳免疫。
