单剂量低抗原无细胞百日咳疫苗在未接种疫苗青少年人群中的免疫原性。
Immunogenicity of a single dose of reduced-antigen acellular pertussis vaccine in a non-vaccinated adolescent population.
作者信息
Knuf Markus, Zepp Fred, Meyer Claudius, Grzegowski Edith, Wolter Joanne, Riffelmann Marion, Wirsing von König Carl Heinz
机构信息
Department of Pediatrics, Johannes Gutenberg University of Mainz, Germany.
出版信息
Vaccine. 2006 Mar 15;24(12):2043-8. doi: 10.1016/j.vaccine.2005.11.024. Epub 2005 Nov 28.
German adolescents (n=123) without previous pertussis vaccination, no history of pertussis and low IgG-anti-pertussis-toxin (PT) levels received one dose of the Tdap vaccine Boostrix. Blood samples were taken before, and 5-12 days and 29-49 days after vaccination. IgG- and IgA-anti-PT, IgG- and IgA-anti filamentous hemagglutinin, IgG-anti-pertactin, IgG-anti-tetanus-toxin, and IgG-anti-diphtheria-toxin were measured by ELISA. 88.6% of subjects had an immune response to PT, and all vaccinees had an immune response to at least one pertussis antigen 29-49 days after vaccination. IgA-anti-PT and IgA-anti-FHA responses were found in 43 and 81% of subjects, respectively. This study shows that in unvaccinated German adolescents pertussis immunity can be achieved by a single dose of Tdap.
123名未曾接种过百日咳疫苗、无百日咳病史且抗百日咳毒素（PT）的IgG水平较低的德国青少年接种了一剂吸附无细胞百白破疫苗（Tdap）“保适博”。在接种前、接种后5 - 12天以及29 - 49天采集血样。通过酶联免疫吸附测定法（ELISA）检测抗PT的IgG和IgA、抗丝状血凝素的IgG和IgA、抗百日咳杆菌黏附素的IgG、抗破伤风毒素的IgG以及抗白喉毒素的IgG。88.6%的受试者对PT产生了免疫反应，并且所有接种者在接种后29 - 49天对至少一种百日咳抗原产生了免疫反应。分别在43%和81%的受试者中发现了抗PT的IgA和抗丝状血凝素（FHA）的IgA反应。这项研究表明，在未接种疫苗的德国青少年中，一剂Tdap疫苗可实现百日咳免疫。
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