Levi D M, Klein S A
University of Houston, College of Optometry Houston, TX 77204-6052.
Neurosci Lett. 1992 Feb 17;136(1):63-6. doi: 10.1016/0304-3940(92)90648-q.
We measured the positional acuity of amblyopic observers and their sensitivity to the local contrast information which provides the cue for the position judgement. Our results suggest that there exist fundamental differences in the neural losses in humans with strabismic and anisometropic amblyopia. The losses in positional acuity of anisometropic amblyopes may be accounted for on the basis of the reduced contrast sensitivity and increased neural pooling of the underlying visual filters; whereas strabismic amblyopes, like the normal periphery, show an extra loss, which may be accounted for on the basis of scrambling, or jitter in the topographic mapping of information from retina to cortex. Since neurons in the striate cortex of monkeys show precise positional coding, it would be of particular interest to examine the positional acuity and local contrast sensitivity in cortical neurons of monkeys with experimental amblyopia using the same stimuli to measure both.
我们测量了弱视观察者的位置敏锐度以及他们对为位置判断提供线索的局部对比度信息的敏感度。我们的结果表明，斜视性弱视和屈光参差性弱视患者在神经损伤方面存在根本差异。屈光参差性弱视患者位置敏锐度的损失可能是由于潜在视觉滤波器的对比度敏感度降低和神经池化增加所致；而斜视性弱视患者，与正常外周视觉一样，表现出额外的损失，这可能是由于从视网膜到皮层的信息地形图发生了扰乱或抖动。由于猴子纹状皮层中的神经元表现出精确的位置编码，因此使用相同的刺激来测量实验性弱视猴子皮层神经元的位置敏锐度和局部对比度敏感度将特别有趣。
