不同的替代方法能否检测出不同相对年代的横向基因转移事件？

Do different surrogate methods detect lateral genetic transfer events of different relative ages?

作者信息

Ragan Mark A, Harlow Timothy J, Beiko Robert G

机构信息

ARC Centre in Bioinformatics and Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.

出版信息

Trends Microbiol. 2006 Jan;14(1):4-8. doi: 10.1016/j.tim.2005.11.004. Epub 2005 Dec 13.

DOI:10.1016/j.tim.2005.11.004

PMID:16356716

Abstract

Non-tree-based ("surrogate") methods have been used to identify instances of lateral genetic transfer in microbial genomes but agreement among predictions of different methods can be poor. It has been proposed that this disagreement arises because different surrogate methods are biased towards the detection of certain types of transfer events. This conjecture is supported by a rigorous phylogenetic analysis of 3776 proteins in Escherichia coli K12 MG1655 to map the ages of transfer events relative to one another.

摘要

非基于树的（“替代”）方法已被用于识别微生物基因组中的横向基因转移实例，但不同方法的预测结果之间的一致性可能较差。有人提出，这种不一致的出现是因为不同的替代方法倾向于检测某些类型的转移事件。对大肠杆菌K12 MG1655中的3776种蛋白质进行的严格系统发育分析支持了这一推测，该分析用于绘制转移事件相对于彼此的发生时间。