Meloni A M, Surti U, Contento A M, Davare J, Sandberg A A
Cancer Center, Southwest Biomedical Research Institute and Genetrix, Inc., Scottsdale, Arizona.
Obstet Gynecol. 1992 Aug;80(2):209-17.
The main purpose of this study was to determine whether there is any correlation between the cytogenetic abnormalities and histology in uterine leiomyomas.
A total of 93 benign uterine leiomyomas were included in the study. The majority (88 of 93) were classified as typical benign leiomyomas, four as cellular, and one as atypical symplastic.
A normal chromosome complement (46,XX) was observed in approximately 50% of the cases (41 of 93). Seventeen leiomyomas did not grow sufficiently in culture to yield cells for chromosome analyses. Of the 35 cases with clonal abnormalities, 28 could be divided into four major subgroups, each representing one of the most common abnormalities observed, such as those of chromosomes 1, 7, and 13, and t(12;14).
Our findings indicate that approximately 50% of leiomyomas show clonal abnormalities, which can be subdivided into four different major categories; four of five (80%) of the atypical leiomyomas showed clonal chromosome abnormalities, which in one case were complex. The results indicate that different specific chromosome abnormalities may characterize the same tumor type.
本研究的主要目的是确定子宫平滑肌瘤的细胞遗传学异常与组织学之间是否存在任何相关性。
本研究共纳入93例良性子宫平滑肌瘤。其中大多数（93例中的88例）被归类为典型的良性平滑肌瘤，4例为细胞型，1例为非典型合体细胞型。
在大约50%的病例（93例中的41例）中观察到正常的染色体核型（46,XX）。17例平滑肌瘤在培养中生长不足，无法获得用于染色体分析的细胞。在35例具有克隆性异常的病例中，28例可分为四个主要亚组，每个亚组代表所观察到的最常见异常之一，如染色体1、7和13以及t(12;14)的异常。
我们的研究结果表明，大约50% 的平滑肌瘤显示克隆性异常，可细分为四种不同的主要类别；五分之四（80%）的非典型平滑肌瘤显示克隆性染色体异常，其中一例为复杂异常。结果表明，不同的特定染色体异常可能是同一肿瘤类型的特征。
