Stern C, Deichert U, Thode B, Bartnitzke S, Bullerdiek J
Zentrum für Humangenetik und Genetische Beratung, Universität Bremen.
Geburtshilfe Frauenheilkd. 1992 Dec;52(12):767-72. doi: 10.1055/s-2007-1023809.
A cytogenetic study of 139 uterine leiomyomas of 70 patients is presented. 26 of the tumours failed to grow, 87 showed an apparently normal karyotype and 26 tumours were characterised by clonal aberrations. In 5 tumours, a numerical change was the only abnormality, including 2 tumours with a trisomy 12. 5 myomas showed an interstitial deletion of the long arm of chromosome 7. The largest group were 9 tumours with an aberration involving chromosome 12 in the band of 14-15. 2 myomas showed a t(12; 14) as the only abnormality, in 4 tumours very complex rearrangements with up to 12 breakpoints were observed. In the last group 7 myomas with other clonal aberrations involving 11 different chromosomes were found.
本文呈现了对70例患者的139个子宫平滑肌瘤的细胞遗传学研究。26个肿瘤未能生长，87个显示出明显正常的核型，26个肿瘤具有克隆性畸变特征。在5个肿瘤中，数目改变是唯一的异常，其中包括2个12号染色体三体的肿瘤。5个肌瘤显示7号染色体长臂的间质缺失。最大的一组是9个肿瘤，其畸变涉及12号染色体14-15带。2个肌瘤显示t(12; 14)是唯一的异常，在4个肿瘤中观察到非常复杂的重排，多达12个断点。在最后一组中，发现7个肌瘤具有涉及11条不同染色体的其他克隆性畸变。
