Liley D T J, Bojak I
Centre for Intelligent Systems and Complex Processes, LSS, Swinburne University of Technology, Hawthorn, Australia.
J Clin Neurophysiol. 2005 Oct;22(5):300-13.
A central difficulty in modeling epileptogenesis using biologically plausible computational and mathematical models is not the production of activity characteristic of a seizure, but rather producing it in response to specific and quantifiable physiologic change or pathologic abnormality. This is particularly problematic when it is considered that the pathophysiological genesis of most epilepsies is largely unknown. However, several volatile general anesthetic agents, whose principle targets of action are quantifiably well characterized, are also known to be proconvulsant. The authors describe recent approaches to theoretically describing the electroencephalographic effects of volatile general anesthetic agents that may be able to provide important insights into the physiologic mechanisms that underpin seizure initiation.
使用具有生物学合理性的计算和数学模型来模拟癫痫发生的一个核心困难，不是产生癫痫发作的特征性活动，而是使其对特定且可量化的生理变化或病理异常做出反应。考虑到大多数癫痫的病理生理起源在很大程度上尚不清楚，这一问题就尤为突出。然而，几种挥发性全身麻醉剂，其主要作用靶点已得到很好的量化表征，也已知具有促惊厥作用。作者描述了最近在理论上描述挥发性全身麻醉剂脑电图效应的方法，这些方法可能能够为癫痫发作起始的生理机制提供重要见解。
