Perquin M, Michel G H, de Beaufort C, Keipes M, Wirion R, Haas N
CRP-Santé, CES, Service of Clinical Epidemiology and Public Health, BP 2021 L- 1020 Luxembourg, Luxembourg.
Diabetes Metab. 2005 Nov;31(5):499-502. doi: 10.1016/s1262-3636(07)70222-7.
The aims of the study were to estimate the prevalence of diabetes in Luxembourg in 2002, to compare it to the prevalence reported in 1991 and to evaluate if prescription attitudes have changed since 1991.
The prevalence of diabetes was estimated using the drug sales data. The key parameters, total amount of antidiabetic drugs sold in one year and the average daily dose or Prescribed Daily Dose (PDD), have been obtained from the National Social Security Organization and by a standardized questionnaire sent to all general practitioners and all internists and endocrinologists of the country.
The PDD was calculated on 2, 402 questionnaires on individual diabetic patients. By this means, the proportion of patients only treated with appropriate diet could also be obtained. Compared to 1991, the total amount of antidiabetic drugs showed a four-fold increase in metformine tablet prescriptions. A high percentage of combined treatments was found. The prevalence of diabetes in Luxembourg was found to be 3.05% of the total population.
Compared to the status in 1991, prevalence of diabetes increased by 63%, which seems mainly due to type 2 diabetic patients as orally-treated diabetic patients almost doubled (2.11% vs 1.16%). A substantial change in prescriptions for diabetes has occurred, suggesting a positive influence of studies like the United Kingdom Prospective Diabetes Study (UKPDS).
本研究旨在估算2002年卢森堡糖尿病的患病率，将其与1991年报告的患病率进行比较，并评估自1991年以来处方态度是否发生了变化。
利用药品销售数据估算糖尿病患病率。关键参数，即一年中销售的抗糖尿病药物总量以及平均日剂量或规定日剂量（PDD），已从国家社会保障组织获取，并通过向该国所有全科医生、内科医生和内分泌科医生发送标准化问卷获得。
对2402份关于个体糖尿病患者的问卷计算了PDD。通过这种方式，还可以得出仅接受适当饮食治疗的患者比例。与1991年相比，抗糖尿病药物总量显示二甲双胍片剂处方增加了四倍。发现联合治疗的比例很高。卢森堡糖尿病患病率为总人口的3.05%。
与1991年的情况相比，糖尿病患病率增加了63%，这似乎主要归因于2型糖尿病患者，因为口服治疗的糖尿病患者几乎翻了一番（2.11%对1.16%）。糖尿病处方发生了重大变化，这表明像英国前瞻性糖尿病研究（UKPDS）这样的研究产生了积极影响。
