天门冬对雄性白化Wistar大鼠乙二醇诱导的结石形成的抗结石作用。
Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-induced lithiasis in male albino Wistar rats.
作者信息
Christina A J M, Ashok K, Packialakshmi M, Tobin G C, Preethi J, Murugesh N
机构信息
Department of Pharmacology, K.M. College of Pharmacy, Tamil Nadu, India.
出版信息
Methods Find Exp Clin Pharmacol. 2005 Nov;27(9):633-8. doi: 10.1358/mf.2005.27.9.939338.
The ethanolic extract of Asparagus racemosus Willd. was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. calcium, oxalate, and phosphate, thereby contributing to renal stone formation. The ethanolic extract, however, significantly (p < 0.05) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitors of crystallization. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced, following treatment with the extract. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for the conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.
对印度天门冬的乙醇提取物进行了评估，观察其对成年雄性白化Wistar大鼠口服0.75%乙二醇水溶液28天诱导的结石形成（结石症）的抑制潜力。乙二醇改变了尿液的离子化学性质，提高了关键离子即钙、草酸盐和磷酸盐的尿液浓度，从而导致肾结石形成。然而，乙醇提取物显著（p < 0.05）降低了尿液中这些离子的升高水平。此外，它提高了尿液中镁的浓度，镁被认为是结晶抑制剂之一。在用提取物治疗后，乙二醇处理的大鼠中观察到的高血清肌酐水平也有所降低。组织病理学结果也显示，用提取物治疗后有改善迹象。所有这些观察结果为得出该植物提取物抑制乙二醇治疗诱导的结石形成这一结论提供了依据。
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