前列腺素和血小板活化因子对牛睫状肌收缩性的影响。

Effects of prostaglandins and PAF on the contractility of the bovine ciliary muscle.

作者信息

Lograno M D, Daniele E, Giovanazzi S, Guarrera A, Nicosia S

机构信息

Department of Pharmacobiology, University of Bari, Italy.

出版信息

Pharmacol Res. 1992 Feb-Mar;25(2):195-202. doi: 10.1016/1043-6618(92)91388-w.

DOI:10.1016/1043-6618(92)91388-w

PMID:1635897

Abstract

The present study has investigated the effect of prostaglandins and PAF on the contractility of the bovine ciliary muscle, a tissue involved in the control of aqueous outflow. The results show that the prostaglandins tested (PGI2, its stable analogue Iloprost, PGE2, PGE1, and PGF2 alpha) as well as PAF, were able to contract the ciliary muscle, although with different potencies and efficacies. PGI2 and Iloprost displayed parallel dose-effect curves with upper plateaus that did not differ significantly; however, PGI2 was slightly more potent than Iloprost. This is at variance with what is observed at the level of the platelet prostacyclin receptor. PGF2 alpha was equipotent with the PGEs tested, with a maximal effect not different from either PGI2 or PGEs. PAF was the most efficacious of the compounds tested.

摘要

本研究调查了前列腺素和血小板活化因子对牛睫状肌收缩性的影响，睫状肌是参与房水流出控制的一种组织。结果表明，所测试的前列腺素（前列环素（PGI2）、其稳定类似物伊洛前列素、前列腺素E2（PGE2）、前列腺素E1（PGE1）和前列腺素F2α（PGF2α））以及血小板活化因子均能够使睫状肌收缩，尽管其效力和效能有所不同。PGI2和伊洛前列素呈现出平行的剂量-效应曲线，其平台期上限无显著差异；然而，PGI2的效力略高于伊洛前列素。这与在血小板前列环素受体水平所观察到的情况不同。PGF2α与所测试的前列腺素E效力相当，其最大效应与PGI2或前列腺素E均无差异。血小板活化因子在所测试的化合物中效能最高。