某些前列腺素和前列腺素类似物对小鼠PAF诱导休克的影响。

Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice.

作者信息

Becker K, Herfurth M L, Schillinger E, Förster W

机构信息

Martin Luther University Halle-Wittenberg, Department of Pharmacology and Toxicology, GDR.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1990 Jun;40(2):157-60. doi: 10.1016/0952-3278(90)90159-i.

DOI:10.1016/0952-3278(90)90159-i

PMID:1696744

Abstract

Prostaglandins and Prostaglandin-analogues were investigated for their ability to protect mice from platelet-activating factor (PAF) induced shock. 75% mortality in female NMRI mice was induced by i.v. injection of 75 micrograms/kg PAF. Nileprost and PGE1, the most potent substances, produced a dose dependent protection against PAF. Iloprost and PGI2 were less effective. PGE2, nalador, flunoprost and U 46619 were neither protective nor deleterious. The strong difference in the effectiveness between the two prostaglandins of the E-series and the poor effect of PGI2 and the PGI2 analogue is remarkable. Flunoprost and U 46619 that increased the TXB2 synthesis or release in two experimental models did not enhance the PAF mortality; TXA2 seems to be only a secondary mediator of the acute PAF-induced death.

摘要

研究了前列腺素及其类似物保护小鼠免受血小板活化因子（PAF）诱导休克的能力。通过静脉注射75微克/千克PAF，雌性NMRI小鼠的死亡率达到75%。最有效的物质尼罗前列素和前列腺素E1对PAF产生了剂量依赖性保护作用。伊洛前列素和前列环素I2效果较差。前列腺素E2、纳拉多、氟诺前列素和U 46619既无保护作用也无有害作用。E系列两种前列腺素之间有效性的巨大差异以及前列环素I2和前列环素I2类似物的低效性值得注意。在两个实验模型中增加血栓素B2合成或释放的氟诺前列素和U 46619并未提高PAF死亡率；血栓素A2似乎只是急性PAF诱导死亡的次要介质。