肾上腺是应激诱导循环白细胞介素-18的来源。
The adrenal gland is a source of stress-induced circulating IL-18.
作者信息
Sugama Shuei, Wang Ning, Shimokawa Noriaki, Koibuchi Noriyuki, Fujita Masayo, Hashimoto Makoto, Dhabhar Firdaus S, Conti Bruno
机构信息
Department of Physiology, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8602, Japan.
出版信息
J Neuroimmunol. 2006 Mar;172(1-2):59-65. doi: 10.1016/j.jneuroim.2005.11.001. Epub 2005 Dec 15.
The present study compared plasma IL-18 levels between sham-operated and adrenalectomized mice following stress to investigate whether the adrenal gland contributes to the elevation of circulating IL-18 during stress. Two hours of stress provoked a robust, stressor-dependent, elevation of IL-18 mRNA and peptide in the adrenal gland in sham-operated mice. Consistently, levels of circulating mature IL-18 increased during stress and remained elevated for up to 6 h after stress. The stress-induced increase in circulating IL-18 was abolished by adrenalectomy. These findings demonstrate that the adrenal gland is required to achieve elevation of circulating IL-18 during stress.
本研究比较了假手术小鼠和肾上腺切除小鼠在应激后血浆白细胞介素-18（IL-18）水平，以研究肾上腺是否在应激期间促使循环IL-18升高。两小时的应激在假手术小鼠的肾上腺中引发了强大的、依赖于应激源的IL-18信使核糖核酸（mRNA）和肽的升高。同样，循环中成熟IL-18的水平在应激期间升高，并在应激后长达6小时保持升高。肾上腺切除术消除了应激诱导的循环IL-18升高。这些发现表明，肾上腺是应激期间循环IL-18升高所必需的。
Zotero 插件