Holdsworth P A, Vercruysse J, Rehbein S, Peter R J, De Bruin C, Letonja T, Green P
Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia.
Vet Parasitol. 2006 Feb 28;136(1):15-28. doi: 10.1016/j.vetpar.2005.11.007. Epub 2005 Dec 15.
These guidelines have been prepared to assist in the planning, conduct and interpretation of studies for the assessment of efficacy of ectoparasiticides against the myiasis causing parasites of ruminants. These guidelines specifically focus on larvicidal efficacy against myiasis causing flies. Information is provided on the selection of animals, dose determination and dose confirmation studies, field studies, record keeping and result interpretation. These guidelines advocate the use of pen facilities for dose determination and dose confirmation studies for defining therapeutic and persistent efficacy. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the world-wide adoption of standard procedures.
编写这些指南是为了协助规划、开展和解释用于评估杀外寄生虫剂对引起反刍动物蝇蛆病寄生虫的疗效的研究。这些指南特别关注对引起蝇蛆病的苍蝇的杀幼虫效力。提供了关于动物选择、剂量确定和剂量确认研究、田间研究、记录保存和结果解释的信息。这些指南提倡使用围栏设施进行剂量确定和剂量确认研究，以确定治疗效果和持续效力。这些指南还旨在协助研究人员如何进行特定实验，为参与决策过程的注册管理部门提供具体信息，协助新杀外寄生虫剂的批准和注册，并促进全球采用标准程序。
