Holdsworth P A, Vercruysse J, Rehbein S, Peter R J, Letonja T, Green P
Avcare Limited, Locked Bag 916, Canberra, 2601 ACT, Australia.
Vet Parasitol. 2006 Feb 28;136(1):45-54. doi: 10.1016/j.vetpar.2005.11.008. Epub 2005 Dec 15.
These guidelines have been prepared to assist in the design, implementation and interpretation of studies for the assessment of the efficacy of ectoparasiticides against biting and sucking lice and sheep keds on ruminants. Information is provided on the selection of animals, dose determination, dose confirmation and field studies, record keeping and result interpretation. These guidelines advocate the use of pen facilities for dose determination and dose confirmation studies for defining therapeutic and persistent efficacy. These guidelines are also intended to assist investigators on how to conduct specific experiments, to provide specific information for registration authorities involved in the decision making process, to assist in the approval and registration of new ectoparasiticides, and to facilitate the world-wide adoption of standard procedures.
编写这些指南是为了协助设计、实施和解释评估杀外寄生虫剂对反刍动物叮咬性和吸血性虱子及绵羊蜱蝇功效的研究。提供了有关动物选择、剂量确定、剂量确认和田间研究、记录保存及结果解释的信息。这些指南提倡使用围栏设施进行剂量确定和剂量确认研究,以确定治疗效果和持续效果。这些指南还旨在协助研究人员如何进行特定实验,为参与决策过程的注册机构提供具体信息,协助新杀外寄生虫剂的批准和注册,并促进全球采用标准程序。