Rummeny E J, Peters P E
Institut für Klinische Radiologie, Westfälische Wilhelms-Universität, Münster.
Radiologe. 1992 May;32(5):225-31.
MR contrast agents are developed for pharmaceutical manipulation of tissue signal intensities. Today it is widely recognized that MR contrast agents will play an increasingly important role in MR imaging of the liver. Contrast-enhanced MR-imaging allows to obtain simultaneously dynamic physiologic information and high anatomic detail. Up to now three major classes of MR contrast agents are available for clinical MR-imaging of the liver. These include paramagnetic perfusion agents, hepatobiliary agents, and super-paramagnetic RES-specific iron oxide particles. A fourth class of contrast agents now in use for animal experiments includes ultra-small super-paramagnetic particles which can be targeted to extra-reticuloendothelial structures such as asialoglycoprotein receptors of hepatocytes. In this article, we review recent advances in the development of MR contrast media and the clinical status of contrast-enhanced MR imaging of the liver.
磁共振造影剂是为药物操纵组织信号强度而研发的。如今，人们普遍认识到磁共振造影剂在肝脏磁共振成像中将发挥越来越重要的作用。对比增强磁共振成像能够同时获取动态生理信息和高分辨率的解剖细节。到目前为止，有三大类磁共振造影剂可用于肝脏的临床磁共振成像。这些包括顺磁性灌注剂、肝胆剂和超顺磁性网状内皮系统特异性氧化铁颗粒。目前用于动物实验的第四类造影剂包括超小超顺磁性颗粒，其可靶向于肝外网状内皮结构，如肝细胞的去唾液酸糖蛋白受体。在本文中，我们综述了磁共振造影剂研发的最新进展以及肝脏对比增强磁共振成像的临床现状。
