• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多种原小檗碱衍生物的合成及降血糖活性评价

Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.

作者信息

Bian Xiaoli, He Langchong, Yang Guangde

机构信息

School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.

出版信息

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1380-3. doi: 10.1016/j.bmcl.2005.11.045. Epub 2005 Dec 15.

DOI:10.1016/j.bmcl.2005.11.045
PMID:16359864
Abstract

Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.

摘要

合成了多种小檗碱衍生物（2 - 17），并在β-细胞膜色谱模型和四氧嘧啶诱导的糖尿病小鼠模型中评估了它们的降血糖活性。结果表明，化合物5和14具有降血糖活性。讨论了它们的构效关系。

相似文献

1
Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.多种原小檗碱衍生物的合成及降血糖活性评价
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1380-3. doi: 10.1016/j.bmcl.2005.11.045. Epub 2005 Dec 15.
2
Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers.光千金藤块茎中棕榈碱衍生物11-羟基棕榈碱的降血糖作用
J Asian Nat Prod Res. 2010 Feb;12(2):99-105. doi: 10.1080/10286020903117325.
3
Synthesis and antihyperglycemic activity of 2-(substituted phenyl)-3-{[4-(1-naphthyl)-1,3-thiazol-2-yl] amino}-4-oxo-1,3-thiazolidin-5-ylacetic acid derivatives.2-（取代苯基）-3-{[4-（1-萘基）-1,3-噻唑-2-基]氨基}-4-氧代-1,3-噻唑烷-5-基乙酸衍生物的合成及其降血糖活性
Acta Pol Pharm. 2009 Jan-Feb;66(1):51-6.
4
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities.具有潜在降血糖和降血脂活性的亚芳基噻唑烷二酮类化合物的合成、生物学评价及分子模拟研究
Eur J Med Chem. 2007 Oct;42(10):1263-71. doi: 10.1016/j.ejmech.2007.02.015. Epub 2007 Mar 3.
5
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.新型2-芳基萘并[1,2-d]恶唑衍生物作为具有抗高血糖活性的潜在蛋白酪氨酸磷酸酶-1B抑制剂。
Eur J Med Chem. 2009 Jan;44(1):109-16. doi: 10.1016/j.ejmech.2008.03.009. Epub 2008 Mar 27.
6
[Synthesis and biological evaluation of tetrahydrocoptisine quaternary ammonium compounds].
Yao Xue Xue Bao. 2012 Dec;47(12):1640-5.
7
Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.
J Med Chem. 1998 Jul 16;41(15):2754-64. doi: 10.1021/jm970735n.
8
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.设计和合成 2,4-二取代的多氢喹啉类化合物作为有前景的抗高血糖和调脂药物。
Bioorg Med Chem. 2010 Jun 1;18(11):4138-48. doi: 10.1016/j.bmc.2009.11.061. Epub 2009 Dec 6.
9
[Synthesis and biological activity of a series of benzopyran derivatives].一系列苯并吡喃衍生物的合成及生物活性
Yao Xue Xue Bao. 2008 Feb;43(2):162-8.
10
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes.新型咪唑啉衍生物的设计与合成及其在2型糖尿病大鼠模型中的强效降血糖活性研究
Bioorg Med Chem. 2006 Nov 15;14(22):7419-33. doi: 10.1016/j.bmc.2006.07.026. Epub 2006 Aug 2.

引用本文的文献

1
Synthesis and biological evaluation of -inspired antimicrobials.受启发的抗菌剂的合成与生物学评价。
Beilstein J Org Chem. 2023 Sep 29;19:1511-1524. doi: 10.3762/bjoc.19.108. eCollection 2023.
2
Design, synthesis and mechanism study of novel natural-derived isoquinoline derivatives as antifungal agents.新型天然衍生异喹啉衍生物的设计、合成及抗真菌机制研究。
Mol Divers. 2023 Jun;27(3):1011-1022. doi: 10.1007/s11030-022-10463-z. Epub 2022 Jun 6.
3
Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action.
发现首个具有超强作用的9-N-小檗碱衍生物类降血糖药物。
Pharmaceutics. 2021 Dec 12;13(12):2138. doi: 10.3390/pharmaceutics13122138.
4
Screening active components from for pancreatic β-cells protection.从 中筛选具有胰腺β细胞保护作用的活性成分。
Pharm Biol. 2020 Dec;58(1):674-685. doi: 10.1080/13880209.2020.1787467.
5
Syntheses and Structure-Activity Relationships in Growth Inhibition Activity against Human Cancer Cell Lines of 12 Substituted Berberine Derivatives.12 个取代小檗碱衍生物对人癌细胞系生长抑制活性的合成及构效关系研究。
Molecules. 2020 Apr 18;25(8):1871. doi: 10.3390/molecules25081871.
6
as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review.作为2型糖尿病的潜在治疗药物及其潜在机制：综述
Front Pharmacol. 2019 Jul 22;10:805. doi: 10.3389/fphar.2019.00805. eCollection 2019.
7
Novel carbohydrate modified berberine derivatives: synthesis and anti-diabetic investigation.新型碳水化合物修饰的小檗碱衍生物：合成与抗糖尿病研究。
Medchemcomm. 2019 Feb 8;10(4):598-605. doi: 10.1039/c9md00036d. eCollection 2019 Apr 1.
8
A Unified Strategy for the Syntheses of the Isoquinolinium Alkaloids Berberine, Coptisine, and Jatrorrhizine.一种异喹啉类生物碱小檗碱、黄连碱和吴茱萸碱的统一合成策略。
Org Lett. 2018 Jul 20;20(14):4281-4284. doi: 10.1021/acs.orglett.8b01702. Epub 2018 Jun 28.
9
Application of berberine on treating type 2 diabetes mellitus.小檗碱治疗 2 型糖尿病的应用。
Int J Endocrinol. 2015;2015:905749. doi: 10.1155/2015/905749. Epub 2015 Mar 11.
10
Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients.小檗碱和伊曲康唑对临床分离烟曲霉体外无协同作用。
Molecules. 2011 Nov 3;16(11):9218-33. doi: 10.3390/molecules16119218.