多种原小檗碱衍生物的合成及降血糖活性评价
Synthesis and antihyperglycemic evaluation of various protoberberine derivatives.
作者信息
Bian Xiaoli, He Langchong, Yang Guangde
机构信息
School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.
出版信息
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1380-3. doi: 10.1016/j.bmcl.2005.11.045. Epub 2005 Dec 15.
PMID:16359864
Abstract
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of beta-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
摘要
合成了多种小檗碱衍生物（2 - 17），并在β-细胞膜色谱模型和四氧嘧啶诱导的糖尿病小鼠模型中评估了它们的降血糖活性。结果表明，化合物5和14具有降血糖活性。讨论了它们的构效关系。
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