作为2型糖尿病的潜在治疗药物及其潜在机制：综述
as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review.
作者信息
Ran Qian, Wang Jin, Wang Lin, Zeng Hai-Rong, Yang Xiang-Bo, Huang Qin-Wan
机构信息
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ya'an Xun Kang Pharmaceutical Co., Ltd, Ya'an, China.
出版信息
Front Pharmacol. 2019 Jul 22;10:805. doi: 10.3389/fphar.2019.00805. eCollection 2019.
Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a significant public health burden. (RC), known as , is widely used for treating diabetes in China. The bioactive compounds of RC, especially alkaloids, have the potential to suppress T2DM-induced lesions, including diabetic vascular dysfunction, diabetic heart disease, diabetic hyperlipidemia, diabetic nephropathy, diabetic encephalopathy, diabetic osteopathy, diabetic enteropathy, and diabetic retinopathy. This review summarizes the effects of RC and its bioactive compounds on T2DM and T2DM complications. Less research has been conducted on non-alkaloid fractions of RC, which may exert synergistic action with alkaloids. Moreover, we summarized the pharmacokinetic properties and structure-activity relationships of RC on T2DM with reference to extant literature and showed clearly that RC has potential therapeutic effect on T2DM.
糖尿病，尤其是2型糖尿病（T2DM），已成为一项重大的公共卫生负担。在中国，已知的某某（此处原文未明确写出具体名称）被广泛用于治疗糖尿病。某某（此处原文未明确写出具体名称）的生物活性化合物，尤其是生物碱，具有抑制T2DM引发病变的潜力，这些病变包括糖尿病血管功能障碍、糖尿病性心脏病、糖尿病高脂血症、糖尿病肾病、糖尿病脑病、糖尿病骨病、糖尿病肠病和糖尿病视网膜病变。本综述总结了某某（此处原文未明确写出具体名称）及其生物活性化合物对T2DM和T2DM并发症的影响。对某某（此处原文未明确写出具体名称）的非生物碱部分开展的研究较少，其可能与生物碱发挥协同作用。此外，我们参考现有文献总结了某某（此处原文未明确写出具体名称）对T2DM的药代动力学特性和构效关系，并明确表明某某（此处原文未明确写出具体名称）对T2DM具有潜在治疗作用。
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