人胎儿及成人卵巢中的瘦素及其受体。

Leptin and its receptors in human fetal and adult ovaries.

作者信息

Abir Ronit, Ao Asangla, Jin Shaoguang, Barnett Miriam, Raanani Hila, Ben-Haroush Avi, Fisch Benjamin

机构信息

Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.

出版信息

Fertil Steril. 2005 Dec;84(6):1779-82. doi: 10.1016/j.fertnstert.2005.05.067.

DOI:10.1016/j.fertnstert.2005.05.067

PMID:16359991

Abstract

The objective of the study was to investigate the immunocytochemical expression and presence of messenger RNA (mRNA) transcripts for leptin and its receptors in ovaries from human adults and adolescents and second- and third-trimester fetuses. Staining for leptin and the long form of its receptor was identified in oocytes of follicles from primordial stages onward, and for leptin only in granulosa cells of a minority of the samples. Expression of mRNA transcripts for both ligands was detected in all the samples tested.

摘要

该研究的目的是调查瘦素及其受体的信使核糖核酸（mRNA）转录物在成年和青少年人类以及孕中期和孕晚期胎儿卵巢中的免疫细胞化学表达及存在情况。从原始卵泡阶段起，在卵泡的卵母细胞中就可检测到瘦素及其长型受体的染色，而仅在少数样本的颗粒细胞中可检测到瘦素染色。在所有检测样本中均检测到了两种配体的mRNA转录物表达。