Vanhoutte Davy, Schellings Mark, Pinto Yigal, Heymans Stephane
Molecular and Vascular Biology and Center for Transgene Technology and Gene Therapy, University of Leuven, Belgium.
Cardiovasc Res. 2006 Feb 15;69(3):604-13. doi: 10.1016/j.cardiores.2005.10.002. Epub 2005 Dec 19.
The post-myocardial infarction wound repair process involves temporarily overlapping phases that include inflammation, formation of granulation tissue, scar formation, and overall left ventricle (LV) remodelling. The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myocardial infarction (MI). The main proteolytic system involved in the degradation of the ECM in the heart is the matrix metalloproteinase (MMPs) system. The present review will focus on the importance of the unique temporal and spatial window of MMPs and their inhibitors (TIMPs) within the different wound healing phases post-MI. It summarizes (1) the MMP/TIMP levels at different time points post-MI, (2) the alterations seen in post-MI healing in genetically modified mice, and (3) the effects and limitations of therapeutic MMP-inhibition post-MI.
心肌梗死后的伤口修复过程包括多个阶段的暂时重叠，这些阶段包括炎症、肉芽组织形成、瘢痕形成以及左心室（LV）整体重塑。心肌细胞外基质（ECM）在维持心脏的结构和功能完整性方面发挥着重要作用，并且在心肌梗死（MI）后的伤口修复过程中起着核心作用。心脏中参与ECM降解的主要蛋白水解系统是基质金属蛋白酶（MMPs）系统。本综述将聚焦于MMPs及其抑制剂（TIMPs）在MI后不同伤口愈合阶段独特的时空窗口的重要性。它总结了（1）MI后不同时间点的MMP/TIMP水平，（2）转基因小鼠MI后愈合过程中的变化，以及（3）MI后治疗性MMP抑制的效果和局限性。
