Anker Markus S, Rashid Ahmed Mustafa, Butler Javed, Khan Muhammad Shahzeb
German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.
Berlin Institute of Health Center for Regenerative Therapies (BCRT), Berlin, Germany.
Basic Res Cardiol. 2025 Feb;120(1):25-34. doi: 10.1007/s00395-024-01079-5. Epub 2024 Sep 23.
Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly patients are particularly more susceptible as cancer-associated cardiac complications present in advanced stage cancer. These patients may often present with symptoms observed in chronic heart failure (HF). Cardiac wasting, commonly observed in these patients, is a multifaceted syndrome characterized by systemic metabolic alterations and inflammatory processes that specifically affect cardiac function and structure. Experimental and clinical studies have demonstrated that cancer-associated cardiac wasting is linked with cardiac atrophy and altered cardiac morphology, which impairs cardiac function, particularly pertaining to the left ventricle. Therefore, this review aims to present a summary of epidemiologic data and pathophysiological mechanisms of cardiac wasting due to cancer, and future directions in this field.
癌症患者面临着心血管死亡的重大风险，无论自癌症诊断以来的时间长短。老年患者尤其更容易受到影响，因为癌症相关的心脏并发症出现在晚期癌症中。这些患者常常会出现慢性心力衰竭（HF）中观察到的症状。在这些患者中常见的心脏消耗是一种多方面的综合征，其特征是全身代谢改变和炎症过程，这些过程特别影响心脏功能和结构。实验和临床研究表明，癌症相关的心脏消耗与心脏萎缩和心脏形态改变有关，这会损害心脏功能，尤其是左心室功能。因此，本综述旨在总结癌症导致心脏消耗的流行病学数据和病理生理机制，以及该领域的未来发展方向。
