Zabala Arantzazu, Robles Olalla, Parellada Mara, Moreno Dolores Maria, Ruiz-Sancho Ana, Burdalo Maite, Medina Oscar, Arango Celso
Unidad de Adolescentes, Departamento de Psiquiatría, Hospital General Universitario Gregorio Marañón, C/Ibiza 43, 28009 Madrid, Spain.
Eur Psychiatry. 2006 Jul;21(5):283-7. doi: 10.1016/j.eurpsy.2005.09.006. Epub 2005 Dec 19.
The purpose of this study is to determine the decrease of neurological soft signs (NSS) during adolescence and to compare this evolutionary process in two groups of adolescents with first episode psychosis: a) schizophrenia and b) non-schizophrenia patients. The structured neurological evaluation scale (NES) was administered to 24 adolescents with first episode psychosis. The number of NSS, the total and subscales scores were correlated with age in patients and in 39 healthy controls. Adolescents with first-episode psychosis had a higher prevalence of NSS than healthy controls; the schizophrenia patients (N=9) scored higher than non-schizophrenia patients (N=15). The number of NSS, total score and the scores on three of the four NES subscales correlated inversely with age in the healthy control group. No correlation was found for the schizophrenia group. For the non-schizophrenia group, a significant negative correlation was found only in one subscale. The decrease of NSS during adolescence in the healthy population but not in the patient groups with psychosis may be an indicator of a disturbance of brain processes that occurs during development. We did not find a clear pattern of NSS that distinguished schizophrenia from other psychoses.
本研究的目的是确定青少年期神经软体征（NSS）的减少情况，并比较两组首发精神病青少年的这一演变过程：a）精神分裂症患者和b）非精神分裂症患者。对24名首发精神病青少年进行了结构化神经评估量表（NES）测试。将患者及39名健康对照者的NSS数量、总分及各子量表得分与年龄进行相关性分析。首发精神病青少年的NSS患病率高于健康对照者；精神分裂症患者（N = 9）得分高于非精神分裂症患者（N = 15）。在健康对照组中，NSS数量、总分及NES四个子量表中三个子量表的得分与年龄呈负相关。精神分裂症组未发现相关性。对于非精神分裂症组，仅在一个子量表中发现显著负相关。健康人群在青少年期NSS减少，而精神病患者组未减少，这可能表明发育过程中大脑进程出现了紊乱。我们未发现能区分精神分裂症与其他精神病的NSS明确模式。
