Bobryshev Yuri V
Surgical Professorial Unit, St Vincent's Hospital, 234 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.
Micron. 2006;37(3):208-22. doi: 10.1016/j.micron.2005.10.007. Epub 2005 Nov 9.
Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of monocytes with activated endothelium are crucial events leading to atherosclerotic alteration of the arterial intima. In early atherosclerosis, monocytes migrate into the subendothelial layer of the intima where they differentiate into macrophages or dendritic cells. In the subendothelial space enriched with atherogenic lipoproteins, most macrophages transform into foam cells. Foam cells aggregate to form the atheromatous core and as this process progresses, the atheromatous centres of plaques become necrotic, consisting of lipids, cholesterol crystals and cell debris. This review highlights some aspects of monocyte recruitment and foam cell formation in atherosclerosis.
动脉粥样硬化是一种慢性免疫炎症性疾病，其中单核细胞与活化内皮细胞的相互作用是导致动脉内膜发生动脉粥样硬化改变的关键事件。在动脉粥样硬化早期，单核细胞迁移到内膜的内皮下层，在那里它们分化为巨噬细胞或树突状细胞。在富含致动脉粥样硬化脂蛋白的内皮下空间，大多数巨噬细胞转化为泡沫细胞。泡沫细胞聚集形成粥样核心，随着这个过程的进展，斑块的粥样中心会发生坏死，由脂质、胆固醇晶体和细胞碎片组成。本综述重点介绍了动脉粥样硬化中单核细胞募集和泡沫细胞形成的一些方面。
