Arikan Osman Kursat, Birol Ahu, Tuncez Fatma, Erkek Emel, Koc Can
Department of Otorhinolaryngology-Head and Neck Surgery, Kirikkale University School of Medicine, Kirikkale, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jan;101(1):e1-5. doi: 10.1016/j.tripleo.2005.07.035. Epub 2005 Nov 11.
Tissue cooling has long been used in the management of both acute and chronic pain.
To determine whether the application of cryotherapy can reduce the pain of patients with minor form of recurrent aphthous stomatitis.
Twenty adult patients who had 2 discrete aphthous stomatitides in the labial mucosa at the same time were included in this prospective, randomized, and placebo-controlled study. One of the 2 aphthous stomatitides was treated with cryotherapy, the other serving as a control. The pain of aphthous stomatitis was scored by the patient on a 6-point scale (from 0 to 5). The size of the aphthous stomatitis was also measured.
At any interval, no statistical difference was found between the cryotherapy-treated aphthous stomatitis and the control in the change in the value of pain severity, nor was any statistical difference found in the change in the size of the aphthous stomatitis. However, a trend toward less pain in the aphthous stomatitis receiving cryotherapy was noted.
These results suggest that application of cryotherapy on minor form of recurrent oral aphthous stomatitis has no beneficial analgesic effect compared to placebo.
组织冷却长期以来一直用于急性和慢性疼痛的治疗。
确定冷冻疗法的应用是否能减轻轻度复发性阿弗他口炎患者的疼痛。
本前瞻性、随机、安慰剂对照研究纳入了20名成年患者，这些患者同时在唇黏膜处有2个离散的阿弗他口炎病灶。2个阿弗他口炎病灶中的1个采用冷冻疗法治疗，另1个作为对照。患者对阿弗他口炎的疼痛进行6分制评分（从0到5）。还测量了阿弗他口炎的大小。
在任何时间间隔，冷冻疗法治疗的阿弗他口炎与对照在疼痛严重程度值的变化方面均未发现统计学差异，在阿弗他口炎大小的变化方面也未发现任何统计学差异。然而，注意到接受冷冻疗法的阿弗他口炎有疼痛减轻的趋势。
这些结果表明，与安慰剂相比，对轻度复发性口腔阿弗他口炎应用冷冻疗法没有有益的镇痛效果。
