Gorsky Meir, Epstein Joel, Raviv Alon, Yaniv Roni, Truelove Edmond
Department of Oral Pathology and Oral Medicine, the Maurice and Gabriella Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
Spec Care Dentist. 2008 Jan-Feb;28(1):27-31. doi: 10.1111/j.1754-4505.2008.00006.x.
Recurrent aphthous stomatitis (RAS) is a common ulcerative condition of the oral mucosa. In this study, minocycline oral rinses were compared to a placebo in patients suffering from frequent episodes of RAS. Thirty-three patients with RAS were randomly allocated to topical therapy with 0.2% minocycline or a placebo aqueous solution mouthwash. Seven patients also participated in a blind crossover study. The intensity of pain was recorded daily using a visual analogue scale. Minocycline mouthwashes resulted in significant reduction in the severity and duration of pain due to RAS. The findings in the subgroup that participated in the crossover were consistent with outcomes in the randomized study. The findings of this study show that minocycline oral rinses reduce pain in patients with RAS and may have implications for the use of minocycline in other non-infectious inflammatory ulcerative oral mucosal diseases.
复发性阿弗他口炎（RAS）是一种常见的口腔黏膜溃疡性疾病。在本研究中，对米诺环素口腔含漱液与安慰剂在频繁发作RAS的患者中进行了比较。33例RAS患者被随机分配接受0.2%米诺环素或安慰剂水溶液漱口水的局部治疗。7例患者还参与了一项双盲交叉研究。每天使用视觉模拟量表记录疼痛强度。米诺环素漱口水使RAS引起的疼痛严重程度和持续时间显著降低。参与交叉研究的亚组中的结果与随机研究的结果一致。本研究结果表明，米诺环素口腔含漱液可减轻RAS患者的疼痛，并且可能对米诺环素在其他非感染性炎性溃疡性口腔黏膜疾病中的应用具有启示意义。
