Meléndez-Herrera Esperanza, Varela-Echavarría Alfredo
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-UAQ Juriquilla, Querétaro 76230, México.
Brain Res. 2006 Jan 5;1067(1):126-37. doi: 10.1016/j.brainres.2005.10.028. Epub 2005 Dec 19.
Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redundant patterns. In the present work, we compared the brain expression patterns of the class III semaphorins 3A, 3C, and 3F and neuropilins 1 and 2 between mouse and chick embryos at early developmental stages. Our studies revealed that expression of semaphorins is restricted in some cases to neuromeric transverse domains, to specific neuromeric boundaries, and to specific neuronal populations. Moreover, our studies also revealed coexpression of neuropilins and one or more semaphorins in some of the different expression sites. Comparison of the expression patterns between mouse and chick embryos showed large similarities, but important differences were also detected.
信号素构成一类信号分子家族，在轴突导向和神经元迁移中发挥作用。神经纤毛蛋白1和2已被确定为信号素受体的配体结合成分。配体和受体在胚胎和成年器官中以互补且有时冗余的模式表达。在本研究中，我们比较了小鼠和鸡胚胎早期发育阶段III类信号素3A、3C和3F以及神经纤毛蛋白1和2在脑中的表达模式。我们的研究表明，在某些情况下，信号素的表达局限于神经节横域、特定的神经节边界以及特定的神经元群体。此外，我们的研究还揭示了在一些不同的表达位点神经纤毛蛋白与一种或多种信号素的共表达。小鼠和鸡胚胎表达模式的比较显示出很大的相似性，但也检测到了重要的差异。
