Meadows Kenyon M, Amdur Robert J, Morris Christopher G, Villaret Douglas B, Mazzaferri Ernest L, Mendenhall William M
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.
Am J Otolaryngol. 2006 Jan-Feb;27(1):24-8. doi: 10.1016/j.amjoto.2005.05.017.
To evaluate the efficacy of external beam radiation therapy (EBRT) for differentiated thyroid carcinomas.
Forty-two patients with a locally advanced or recurrent differentiated thyroid carcinoma received high-dose EBRT. Thirty-three patients had local-regional disease and 9 patients also had asymptomatic disease metastases. Twenty patients (48%) had macroscopic local-regional disease before EBRT.
The 5-year outcomes for the overall population and for the subset of those without distant metastases before EBRT were local-regional control (88% and 89%, respectively), cause-specific survival (80% and 86%, respectively), and overall survival (54% and 60%, respectively). Local-regional control was improved for patients with microscopic residual disease compared with macroscopic disease, those with previously untreated tumors, and for those who received more than 64 Gy.
EBRT increases the likelihood of local-regional control for patients with locally advanced differentiated thyroid carcinoma.
评估外照射放疗（EBRT）治疗分化型甲状腺癌的疗效。
42例局部晚期或复发性分化型甲状腺癌患者接受了高剂量EBRT。33例患者有局部区域病变，9例患者同时有无症状疾病转移。20例患者（48%）在EBRT前有肉眼可见的局部区域病变。
总体人群以及EBRT前无远处转移亚组的5年结局为局部区域控制率（分别为88%和89%）、病因特异性生存率（分别为80%和86%）以及总生存率（分别为54%和60%）。与有肉眼可见病变的患者、既往未治疗肿瘤的患者以及接受超过64 Gy照射的患者相比，有微小残留病变的患者局部区域控制情况得到改善。
EBRT提高了局部晚期分化型甲状腺癌患者局部区域控制的可能性。
