循环胰岛素水平低的胰岛素瘤：胰岛素原测量的诊断价值

Insulinoma with low circulating insulin levels: the diagnostic value of proinsulin measurements.

作者信息

Alsever R N, Roberts J P, Gerber J G, Mako M E, Rubenstein A H

出版信息

Ann Intern Med. 1975 Mar;82(3):347-50. doi: 10.7326/0003-4819-82-3-347.

Abstract

Hypoglycemia coexisting with very low plasma immunoreactive insulin concentrations was found in a 78-year-old woman with an insulinoma. However, the absolute proinsulin levels during hypoglycemia were elevated (0.9 to 1.4 ng/ml), accounting for 66.5% of the total circulating immunoreactive insulinlike material. The raised serum proinsulin concentrations together with an abnormal proinsulin:insulin ratio proved to be of critical importance in establishing the diagnosis of an islet-cell tumor in this patient.

摘要

在一名患有胰岛素瘤的78岁女性中发现低血糖与极低的血浆免疫反应性胰岛素浓度并存。然而，低血糖期间的胰岛素原绝对水平升高（0.9至1.4 ng/ml），占循环中总免疫反应性胰岛素样物质的66.5%。血清胰岛素原浓度升高以及胰岛素原与胰岛素的异常比值被证明对该患者胰岛细胞瘤的诊断至关重要。