偏头痛与雌激素受体1（ESR1）基因G325C多态性的关联。

Association of migraine and ESR1 G325C polymorphism.

作者信息

Oterino Agustín, Pascual Julio, Ruiz de Alegría Carlos, Valle Natalia, Castillo Jesús, Bravo Yolanda, González Félix, Sánchez-Velasco Pablo, Cayón Amalia, Leyva-Cobián Francisco, Alonso-Arranz Ana, Muñoz Pedro

机构信息

Services of Neurology, Universitary Hospital Marqués de Valdecilla, Santander, Spain.

出版信息

Neuroreport. 2006 Jan 23;17(1):61-4. doi: 10.1097/01.wnr.0000192735.85287.f4.

DOI:10.1097/01.wnr.0000192735.85287.f4

PMID:16361951

Abstract

Migraine is a genetically complex disorder in which sexual hormones influence the phenotype. ESR1 G594A polymorphism has been associated with migraine in Australians. We performed a case-control study with G594A and G325C polymorphisms to determine whether ESR1 is associated with migraine in our population. An association between G594A and migraine could not be demonstrated here. By contrast, we observed that the C325 allele conferred a 1.6 (95% confidence interval=1.1-2.4) higher risk for suffering from migraine in women than the G allele. Women carrying the C352C genotype were over 3 times more likely to suffer from migraine than those carrying the G325G genotype. Therefore, we conclude that ESR1 G325C polymorphism is associated with migraine in our population.

摘要

偏头痛是一种受性激素影响表型的基因复杂疾病。在澳大利亚人中，ESR1基因的G594A多态性与偏头痛有关。我们对G594A和G325C多态性进行了一项病例对照研究，以确定ESR1基因在我们的人群中是否与偏头痛有关。在此研究中未能证实G594A与偏头痛之间存在关联。相比之下，我们观察到，在女性中，C325等位基因患偏头痛的风险比G等位基因高1.6倍（95%置信区间=1.1 - 2.4）。携带C352C基因型的女性患偏头痛的可能性是携带G325G基因型女性的3倍多。因此，我们得出结论，ESR1基因的G325C多态性与我们人群中的偏头痛有关。