Ranjan Shovit, Paikaray Akshita, Mishra Ankur, Sethi Aman, Dhurua Dibenwita, Panda Aditya K
University Department of Zoology, Kolhan University, Chaibasa, 833201, Jharkhand, India.
ImmGen EvSys Lab, BT-113 Department of Biotechnology, Berhampur University, Bhanja Bihar Berhampur, Berhampur, 760007, Odisha, India.
Curr Pain Headache Rep. 2025 Jan 29;29(1):41. doi: 10.1007/s11916-024-01338-z.
Migraine is a highly prevalent and incapacitating neurological disorder mostly characterised by recurring attacks of moderate to severe throbbing and pulsating pain on one side of the head. The role of estrogen in migraine has been well documented. Although genetic variations in the ESR1 gene have been associated with an increased risk of developing migraine, the findings are inconsistent. We performed a meta-analysis of previously published articles considering four important single nucleotide polymorphisms in the ESR1 gene (rs1801132, rs2228480, rs2234693, and rs9340799) to explore their possible association with the development of migraine and its clinical phenotypes.
We thoroughly searched literature databases, including PubMed, Science Direct, and Scopus until March 14, 2024, to identify the relevant reports. We utilized GPower software v.3 to assess the power of each report included in the meta-analysis and Comprehensive Meta-analysis v4 for all meta-analysis-related analyses. We employed funnel plots and Egger's regression test to identify publication biases within each genetic comparison model. We used Cochrane Q statistics, probability value, and I to assess heterogeneity.
After applying predefined criteria, a meta-analysis was conducted with 11 relevant studies comprising 3835 cases of migraine and 3655 healthy individuals. The analysis indicated a strong correlation between ESR1 polymorphisms (rs2228480 and rs9340799) and the likelihood of developing migraine. Furthermore, the subgroup analysis showed that rs2228480 is associated with susceptibility to migraine in both Caucasians and Asians. Additionally, rs2234693 variants were found to be linked with the development of migraine with aura. However, the trial sequential analysis suggested that more case-control studies are necessary to establish the definitive role of ESR1 variants in migraine.
ESR1 variants (rs2228480, rs2234693, and rs9340799) are associated with an increased risk of migraine and related phenotypes. However, further studies are needed to establish a definitive conclusion.
偏头痛是一种高度流行且使人丧失能力的神经系统疾病，其主要特征为头部一侧反复出现中度至重度的搏动性疼痛。雌激素在偏头痛中的作用已有充分记录。尽管雌激素受体1（ESR1）基因的遗传变异与患偏头痛风险增加有关，但其研究结果并不一致。我们对之前发表的文章进行了一项荟萃分析，考虑了ESR1基因中的四个重要单核苷酸多态性（rs1801132、rs2228480、rs2234693和rs9340799），以探讨它们与偏头痛及其临床表型发生之间的可能关联。
我们全面检索了文献数据库，包括PubMed、Science Direct和Scopus，直至2024年3月14日，以识别相关报告。我们使用GPower软件v.3评估荟萃分析中纳入的每份报告的效能，并使用综合荟萃分析v4进行所有与荟萃分析相关的分析。我们采用漏斗图和埃格回归检验来识别每个基因比较模型中的发表偏倚。我们使用Cochrane Q统计量、概率值和I²来评估异质性。
应用预定义标准后，对11项相关研究进行了荟萃分析，这些研究包括3835例偏头痛患者和3655名健康个体。分析表明，ESR1基因多态性（rs2228480和rs9340799）与患偏头痛的可能性之间存在强烈关联。此外，亚组分析表明，rs2228480与白种人和亚洲人患偏头痛的易感性均有关联。此外，发现rs2234693变异与伴有先兆的偏头痛的发生有关。然而，试验序贯分析表明，需要更多的病例对照研究来确定ESR1变异在偏头痛中的明确作用。
ESR1变异（rs2228480、rs2234693和rs9340799）与偏头痛及相关表型的风险增加有关。然而，需要进一步研究才能得出明确结论。
