Department of Biophysics, Medical School, Duzce University, Duzce, 81620, Turkey,
Cell Mol Neurobiol. 2013 Nov;33(8):1055-63. doi: 10.1007/s10571-013-9972-1. Epub 2013 Aug 22.
We investigated whether there is any relationship between biochemical and clinical parameters of migraine and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism, associated with the migraine subtypes, symptoms, and gender. A total of 150 migraine patients with and without aura (MA and MO) and 107 non-sufferers were included in the study. Biochemical and clinical parameters were measured and genetic analysis was performed. The MTFHR C677T genotype was significantly higher in the migraine group (p = 0.000). The CT genotype frequency of individuals with a family history of migraine was significantly higher (p = 0.025). This genotype frequency was higher in patients who suffer from compression, allodynia, fatigue, and sleeplessness (p = 0.027, 0.023, 0.006, and 0.05, respectively). Homocysteine and total cholesterol levels were significantly higher in the migraine group than the control group (p = 0.007 and 0.010, respectively). However, the other biochemical and clinical parameters did not differ from each other (p > 0.05), with only attack frequency being significantly higher in the MO group (p = 0.005). While the folate and HDL levels were significantly higher in females (p = 0.001 and 0.000, respectively), the homocysteine and triglyceride levels were significantly higher in males (p = 0.000 for each one). BMIs were significantly lower in the control than the migraine group (p = 0.021); however, an association between the C677T variant and BMI was not found (p = 0.787) in the migraine group. An association between the MTHFR C667T polymorphism and migraine susceptibility was found. Additional studies including genetic, clinic, and biochemical parameters should be conducted to better understand the disease.
我们研究了偏头痛的生化和临床参数与亚组、症状和性别之间是否存在联系，以及与亚甲基四氢叶酸还原酶（MTHFR）基因 C677T 多态性的关系。本研究共纳入 150 例有先兆偏头痛（MA）和无先兆偏头痛（MO）患者及 107 例非偏头痛患者。测量了生化和临床参数，并进行了基因分析。偏头痛组 MTFHR C677T 基因型明显更高（p = 0.000）。有偏头痛家族史的个体 CT 基因型频率明显更高（p = 0.025）。该基因型频率在遭受压迫、痛觉过敏、疲劳和失眠的患者中更高（p = 0.027、0.023、0.006 和 0.05）。与对照组相比，偏头痛组患者的同型半胱氨酸和总胆固醇水平明显更高（p = 0.007 和 0.010）。然而，其他生化和临床参数之间没有差异（p > 0.05），MO 组的发作频率明显更高（p = 0.005）。女性叶酸和 HDL 水平明显更高（p = 0.001 和 0.000），而男性同型半胱氨酸和甘油三酯水平明显更高（p = 0.000）。与偏头痛组相比，对照组的 BMI 明显更低（p = 0.021）；然而，在偏头痛组中未发现 C677T 变体与 BMI 之间存在关联（p = 0.787）。MTHFR C667T 多态性与偏头痛易感性相关。应该进行包括遗传、临床和生化参数的进一步研究，以更好地了解这种疾病。
