应用系统生物学与疟疾

Applied systems biology and malaria.

作者信息

Winzeler Elizabeth A

机构信息

Department of Cell Biology, ICND202, The Scripps Research Institute, La Jolla, California 92037, USA.

出版信息

Nat Rev Microbiol. 2006 Feb;4(2):145-51. doi: 10.1038/nrmicro1327.

DOI:10.1038/nrmicro1327

PMID:16362033

Abstract

One of the goals of systems-biology research is to discover networks and interactions by integrating diverse data sets. So far, systems-biology research has focused on model organisms, which are well characterized and therefore suited to testing new methods. Systems biology has great potential for use in the search for therapies for disease. Here, the potential of systems-biology approaches in the search for new drugs and vaccines to treat malaria is examined.

摘要

系统生物学研究的目标之一是通过整合各种数据集来发现网络和相互作用。到目前为止，系统生物学研究主要集中在模式生物上，这些生物具有良好的特征描述，因此适合用于测试新方法。系统生物学在寻找疾病治疗方法方面具有巨大潜力。在此，我们探讨了系统生物学方法在寻找治疗疟疾的新药和疫苗方面的潜力。