Bucala Richard, Lolis Elias
Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Drug News Perspect. 2005 Sep;18(7):417-26. doi: 10.1358/dnp.2005.18.7.939345.
Autoimmune inflammatory diseases occur commonly in Western populations and include conditions such as juvenile-onset diabetes mellitus, rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus. The precise cause of these diseases remains enigmatic. However, current notions of pathogenesis support an important interplay between host genetics and acquired, or environmental, factors. From an immunologic perspective, autoimmune inflammatory diseases develop as a result of a loss of immune tolerance and the initiation of immune-mediated tissue injury. In the following review, we discuss recent studies pointing to an important role for the upstream mediator macrophage migration inhibitory factor in the effector responses producing autoimmune tissue damage.
自身免疫性炎症性疾病在西方人群中普遍存在，包括青少年型糖尿病、类风湿性关节炎、炎症性肠病和系统性红斑狼疮等病症。这些疾病的确切病因仍然不明。然而，目前的发病机制观点支持宿主遗传学与后天因素或环境因素之间的重要相互作用。从免疫学角度来看，自身免疫性炎症性疾病是由于免疫耐受丧失和免疫介导的组织损伤引发而发展的。在以下综述中，我们讨论了近期的研究，这些研究指出上游介质巨噬细胞迁移抑制因子在产生自身免疫性组织损伤的效应反应中起重要作用。
