通过靶向肾小球系膜细胞和内皮细胞治疗进行性肾脏疾病的新方法。 - Suppr

Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.

作者信息

Maeshima Yohei

机构信息

Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

出版信息

Clin Exp Nephrol. 2005 Dec;9(4):271-281. doi: 10.1007/s10157-005-0388-1.

DOI:10.1007/s10157-005-0388-1

PMID:16362153

Abstract

摘要

相似文献

Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.通过靶向肾小球系膜细胞和内皮细胞治疗进行性肾脏疾病的新方法。

Clin Exp Nephrol. 2005 Dec;9(4):271-281. doi: 10.1007/s10157-005-0388-1.

Interactions of the endothelium and mesangium in glomerular injury.

J Am Soc Nephrol. 1990 Sep;1(3 Suppl 1):S13-20.

Glomerular endothelial cell injury and cross talk in diabetic kidney disease.糖尿病肾病中的肾小球内皮细胞损伤与相互作用

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F287-97. doi: 10.1152/ajprenal.00533.2014. Epub 2014 Nov 19.

Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation.姜黄素改善5/6肾切除大鼠的肾衰竭：炎症的作用。

Am J Physiol Renal Physiol. 2009 May;296(5):F1146-57. doi: 10.1152/ajprenal.90732.2008. Epub 2009 Feb 18.

TGF-β sequestration by mesangial cell integrin αvβ8: A novel mechanism of glomerular endothelial cell regulation.系膜细胞整合素αvβ8对转化生长因子-β的隔离作用：肾小球内皮细胞调节的新机制

Am J Pathol. 2011 Feb;178(2):485-9. doi: 10.1016/j.ajpath.2010.10.038.

Effects of lipids on the pathogenesis of progressive renal failure: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in the prevention of glomerulosclerosis.脂质对进行性肾衰竭发病机制的影响：3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂在预防肾小球硬化中的作用。

Miner Electrolyte Metab. 1996;22(1-3):147-52.

Microchimerism in renal allografts: clinicopathological associations according to the type of chimeric cells.肾移植中的微嵌合体：根据嵌合细胞类型的临床病理关联。

Histopathology. 2010 Jan;56(2):188-97. doi: 10.1111/j.1365-2559.2009.03466.x.

Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes.大鼠系膜细胞表现出性别特异性的促纤维化和促炎表型。

Nephrol Dial Transplant. 2009 Jun;24(6):1753-8. doi: 10.1093/ndt/gfn714. Epub 2009 Jan 7.

Plasticity of mesangial cells: a basis for understanding pathological alterations.系膜细胞的可塑性：理解病理改变的基础。

Ultrastruct Pathol. 2006 Nov-Dec;30(6):471-9. doi: 10.1080/01913120600932594.

The role of mesangial homeostasis in glomerular injury progression: hope for mesangial sclerosis reversal.系膜内环境稳定在肾小球损伤进展中的作用：逆转系膜硬化的希望。

Kidney Int. 2009 Mar;75(6):574-6. doi: 10.1038/ki.2008.651.

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Renal-targeted delivery of triptolide by entrapment in pegylated TRX-20-modified liposomes.雷公藤甲素通过包裹于聚乙二醇化TRX - 20修饰脂质体实现肾脏靶向递送。

Int J Nanomedicine. 2017 Aug 8;12:5673-5686. doi: 10.2147/IJN.S141095. eCollection 2017.

Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis.富含花青素的紫玉米提取物可抑制糖尿病相关的肾小球血管生成。

PLoS One. 2013 Nov 20;8(11):e79823. doi: 10.1371/journal.pone.0079823. eCollection 2013.

本文引用的文献

Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model.抗血管生成内皮抑素肽可改善1型糖尿病肾病模型早期的肾脏病变。

Diabetes. 2005 Oct;54(10):2891-903. doi: 10.2337/diabetes.54.10.2891.

Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors.输注血管紧张素II可能通过调节血管生成相关因子，在抗Thy-1.1肾炎早期减少肾小球毛细血管面积的损失。

Kidney Int. 2005 Aug;68(2):704-22. doi: 10.1111/j.1523-1755.2005.00449.x.

Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors.血管生成内源性抑制剂作为内皮细胞特异性肿瘤抑制因子的功能。

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2934-9. doi: 10.1073/pnas.0500180102. Epub 2005 Feb 14.

Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy.肿瘤抑素肽是一种血管生成抑制剂，可预防糖尿病肾病早期的肾小球肥大。

Diabetes. 2004 Jul;53(7):1831-40. doi: 10.2337/diabetes.53.7.1831.

Vascular endothelial growth factor induces protein synthesis in renal epithelial cells: a potential role in diabetic nephropathy.血管内皮生长因子诱导肾上皮细胞中的蛋白质合成：在糖尿病肾病中的潜在作用。

Kidney Int. 2003 Aug;64(2):468-79. doi: 10.1046/j.1523-1755.2003.00135.x.

Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin.肿瘤抑素（胶原蛋白IVα3链的一个片段）的生理水平是由基质金属蛋白酶-9（MMP-9）蛋白水解作用产生的，并通过αVβ3整合素抑制血管生成。

Cancer Cell. 2003 Jun;3(6):589-601. doi: 10.1016/s1535-6108(03)00133-8.

Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth.宿主血管紧张素II 1型受体在肿瘤血管生成和生长中的作用。

J Clin Invest. 2003 Jul;112(1):67-75. doi: 10.1172/JCI16645.

Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis.抗 Thy-1 肾炎中肾单位恢复和丧失的途径

J Am Soc Nephrol. 2003 Jul;14(7):1904-26. doi: 10.1097/01.asn.0000070073.79690.57.

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.人肿瘤抑素和人内皮抑素通过αvβ3和α5β1整合素介导，表现出不同的抗血管生成活性。

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4766-71. doi: 10.1073/pnas.0730882100. Epub 2003 Apr 7.

Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II.在人类糖尿病肾病中，nephrin表达降低：糖化白蛋白和血管紧张素II具有独特作用的证据。

Diabetes. 2003 Apr;52(4):1023-30. doi: 10.2337/diabetes.52.4.1023.

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Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.

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