Maesawa C, Sakuma T
Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan.
Virchows Arch A Pathol Anat Histopathol. 1992;421(1):41-5. doi: 10.1007/BF01607137.
The process of regeneration of white pulp in autotransplanted splenic tissue, implanted into a pocket made by the greater omentum in rats, was investigated histologically and immunohistochemically. Three days after transplantation, almost all implants were necrotic. At day 7, viable splenic tissue had gradually regenerated at the periphery of the implants. At day 10, lymphocytes accumulated around the arterioles. The accumulations resembled the periarteriolar lymphoid sheath of normal spleens in structure, but consisted mainly of B-lymphocytes, with a few scattered T-lymphocytes. However, by week 2, the localization peculiar to T- and B-lymphocytes became definite, and follicular dendritic cells were simultaneously observed in the lymph follicles. This regeneration of the white pulp in the autotransplanted spleens differed from the formation of the white pulp during ontogeny and during recovery after spleen irradiation.
对植入大鼠大网膜所形成囊袋内的自体移植脾组织中白髓的再生过程进行了组织学和免疫组织化学研究。移植后3天，几乎所有植入物均坏死。第7天，植入物周边逐渐再生出存活的脾组织。第10天，淋巴细胞在小动脉周围聚集。这些聚集物在结构上类似于正常脾脏的动脉周围淋巴鞘，但主要由B淋巴细胞组成，有少量散在的T淋巴细胞。然而，到第2周时，T和B淋巴细胞特有的定位变得明确，同时在淋巴滤泡中观察到滤泡树突状细胞。自体移植脾脏中白髓的这种再生不同于个体发育过程中以及脾脏照射后恢复过程中白髓的形成。
