Sasaki K
Department of Anatomy, Yokohama City University School of Medicine, Japan.
APMIS. 1990 Jun;98(6):507-13.
Splenic fragments were autotransplanted into the greater omentum of nude mice (nu/nu) and normal mice to investigate the formation of white pulp in splenic regeneration. The formation of white pulp began from day 5 after transplantation in both groups. Two patterns were found. In one pattern, follicles containing only B cells were first formed and developed into white pulp with poorly developed periarterial lymphoid sheaths (PALS). Most of the white pulp in nude mice and about one third of white pulp formed at day 28 in normal mice followed this pattern. In the second pattern, PALS were first formed and afterwards follicles appeared in the periphery of PALS. This was mainly seen in normal mice. Thus splenic autografts in normal mice contain white pulp with poorly developed PALS, and the homing of T cells begins later than that of B cells. This suggests the possibility of incomplete cellular immunity.
将脾脏碎片自体移植到裸鼠（nu/nu）和正常小鼠的大网膜中，以研究脾脏再生过程中白髓的形成。两组在移植后第5天开始形成白髓。发现了两种模式。在一种模式中，首先形成仅含有B细胞的滤泡，并发育成动脉周围淋巴鞘（PALS）发育不良的白髓。裸鼠中的大多数白髓以及正常小鼠在第28天形成的约三分之一白髓遵循这种模式。在第二种模式中，首先形成PALS，然后在PALS的周边出现滤泡。这主要见于正常小鼠。因此，正常小鼠中的脾脏自体移植包含PALS发育不良的白髓，并且T细胞的归巢比B细胞开始得晚。这表明细胞免疫不完全的可能性。
