质子或立体定向光子照射治疗后葡萄膜黑色素瘤？一项计划对比研究。
Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison.
作者信息
Höcht Stefan, Stark Roland, Seiler Frank, Heufelder Jens, Bechrakis Nikolaos E, Cordini Dino, Marnitz Simone, Kluge Heinz, Foerster Michael H, Hinkelbein Wolfgang
机构信息
Department of Radiooncology and Radiotherapy, Charité - University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
出版信息
Strahlenther Onkol. 2005 Dec;181(12):783-8. doi: 10.1007/s00066-005-1395-6.
BACKGROUND AND PURPOSE
Proton and stereotactic radiotherapy with photons (SRT) are both used to treat choroidal melanomas in proximity to optic disk and fovea centralis, a situation where plaque therapy is prone to complications. A comparative treatment- planning study was done to assess the capability of both modalities to preserve vision.
PATIENTS AND METHODS
In ten patients treated with 68-MeV protons, SRT with 6-MV photons was planned. Structures most important for visual acuity (fovea and optic disk, optic nerve) were contoured identically for both therapies. Safety margins of 1.5 mm for proton therapy were reduced to 1.0 mm for SRT.
RESULTS
Proton-beam therapy was superior in eight of ten situations, and this result did not differ significantly by changes in the weighting of the different parameters analyzed.
CONCLUSION
When dose deposition to those structures most important for the preservation of vision is taken into account, under the conditions examined proton therapy offers an advantage in the majority of the patients evaluated.
背景与目的
质子放疗和立体定向光子放疗（SRT）均用于治疗靠近视盘和中央凹的脉络膜黑色素瘤，在这种情况下，斑块治疗容易出现并发症。进行了一项对比治疗计划研究，以评估这两种治疗方式保留视力的能力。
患者与方法
对10例接受68 MeV质子治疗的患者进行了6 MV光子SRT治疗计划。两种治疗方式对视力最重要的结构（中央凹、视盘、视神经）进行相同的轮廓勾画。质子治疗1.5 mm的安全边界在SRT中减至1.0 mm。
结果
在10种情况中的8种，质子束治疗更具优势，并且该结果在分析的不同参数权重变化时无显著差异。
结论
当考虑对保留视力最重要的那些结构的剂量沉积时，在所研究的条件下，质子治疗在大多数评估患者中具有优势。
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