Herndon R M, Griffin D E, McCormick U, Weiner L P
Arch Neurol. 1975 Jan;32(1):32-5. doi: 10.1001/archneur.1975.00490430054008.
Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.
4周龄的BALB/c小鼠经脑内接种小鼠肝炎病毒JHM株后，发生了急性脱髓鞘疾病，随后明显恢复并伴有髓鞘再生。16个月后对存活小鼠进行检查时，仍存在小面积的活动性脱髓鞘。据我们所知，这是首次报道的实验性病毒感染案例，即急性脱髓鞘恢复后出现持续性或复发性脱髓鞘。
