Lima Araceli, Fehervari T, Paasch L H, Calderón Norma L
Department of Pathology, Section of Clinical Diagnosis, Faculty of Veterinary Medicine and Animal Science, National Autonomous University of Mexico.
Acta Vet Hung. 2005;53(4):501-6. doi: 10.1556/AVet.53.2005.4.10.
In the present study, specific-pathogen-free, 2-week-old Leghorn chickens were experimentally infected with strain 73688 of infectious bursal disease virus (IBDV) in order to evaluate haematological and histological changes that might suggest a pathomechanism for haemorrhages in this disease. At 96 hours post infection (hpi) a significant increase in prothrombin time was detected in the absence of visible lesions in myeloid bone marrow tissue and of significant thrombocytopenia. The aforementioned findings suggest alteration of the secondary coagulation mechanisms and not a direct effect of virus on thrombocytes or its precursors.
在本研究中，为了评估可能提示传染性法氏囊病出血发病机制的血液学和组织学变化，对2周龄的无特定病原体来航鸡进行了传染性法氏囊病病毒（IBDV）73688株的实验性感染。在感染后96小时（hpi），在髓样骨髓组织无可见病变且无明显血小板减少的情况下，检测到凝血酶原时间显著增加。上述发现提示继发性凝血机制发生改变，而非病毒对血小板或其前体的直接作用。
