Inoue M, Fukuda M, Miyano K
Department of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
Avian Dis. 1994 Oct-Dec;38(4):839-46.
Thymic lesions were investigated in specific-pathogen-free chickens infected with the highly virulent HPS-2 strain or virulent reference GBF-1 strain of infectious bursal disease virus (IBDV). Both viruses induced follicular lymphoid necrosis and depletion in the bursa, as well as thymic lesions. However, cortical lymphocyte condensation and depletion in the thymus were more prominent in the HPS-2 group than in the GBF-1 group. Electronmicroscopically, alterations of cortical lymphocytes were characterized by nuclear disintegration resembling apoptosis. Immunohistologically, the virus-antigen-positive epithelial reticular cells in the medulla were more extensive in the HPS-2 group. These results suggest that HPS-2 IBDV persists in the thymic medulla and that cortical lymphocyte depletion is caused by virus-induced apoptosis.
对感染高致病性传染性法氏囊病病毒（IBDV）HPS - 2株或强毒参考GBF - 1株的无特定病原体鸡的胸腺病变进行了研究。两种病毒均引起法氏囊内滤泡性淋巴组织坏死和淋巴细胞耗竭，以及胸腺病变。然而，HPS - 2组胸腺皮质淋巴细胞凝聚和耗竭比GBF - 1组更明显。电镜下，皮质淋巴细胞的改变以类似凋亡的核崩解为特征。免疫组织化学检查显示，HPS - 2组髓质中病毒抗原阳性的上皮网状细胞更为广泛。这些结果表明，HPS - 2 IBDV在胸腺髓质中持续存在，且皮质淋巴细胞耗竭是由病毒诱导的凋亡所致。
