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[胎粪作为检测宫内接触有毒物质的新型生物材料]

[Meconium as a new biological material for detecting intrauterine exposure to toxic substances].

作者信息

Lisowska-Myjak Barbara

机构信息

Katedra i Zakład Biochemii i Chemii Klinicznej, Akademia Medyczna w Warszawie.

出版信息

Ginekol Pol. 2005 Jul;76(7):571-9.

Abstract

The use of licit and illicit drugs and exposure to other xenobiotic agents during pregnancy is common. These substances are known to have adverse effects on the pregnancy and fetus; however information on fetal exposure is sparse due to the lack of an appropriate measure of exposure. Meconium analysis is a new method for identifying in utero exposure of infants to a number of illicit and legal drugs, alcohol, nicotine, heavy metals, pesticides, congenital infections. It's testing is non-invasive, highly accurate and able to detect prior exposure in utero during 12-40 weeks of gestation. This has implications for toxicology to develop improved methods to identify exposed infants.

摘要

孕期使用合法及非法药物以及接触其他外源性物质的情况很常见。已知这些物质会对妊娠和胎儿产生不良影响;然而,由于缺乏合适的暴露测量方法,关于胎儿暴露的信息很少。胎粪分析是一种用于识别婴儿子宫内暴露于多种非法和合法药物、酒精、尼古丁、重金属、农药、先天性感染的新方法。其检测是非侵入性的,高度准确,并且能够检测出妊娠12 - 40周期间子宫内的既往暴露情况。这对毒理学发展改进方法以识别暴露婴儿具有重要意义。

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