Ostrea E M, Matias O, Keane C, Mac E, Utarnachitt R, Ostrea A, Mazhar M
Department of Pediatrics, Hutzel Hospital, Wayne State University, Detroit, Michigan 48201, USA.
J Pediatr. 1998 Oct;133(4):513-5. doi: 10.1016/s0022-3476(98)70059-9.
To detect the spectrum of gestational exposure to illicit drugs and other xenobiotic agents in neonates by meconium analysis.
Meconium was collected from 98 neonates and analyzed for illicit drugs and other xenobiotic agents by high-performance liquid chromatography and gas chromatography/mass spectrometry.
Eighty-one (82.7%) infants tested positive for xenobiotic agents, and each infant had from 1 to 9 drugs present. These included local anesthetics (30%) such as lidocaine and mepivacaine; food additives (25%) such as ionol (butylated hydroxytoluene); illicit drugs (11%), especially cocaine and morphine; analgesics (10%) such as meperidine; and fewer (< 10%) other drugs such as antihistamines, antidepressants, adrenergics, anticonvulsants, cough medications, analeptics, hypnosedatives, and cardiotonics.
We demonstrated substantial exposure of neonates to xenobiotic agents, ranging from exposure to food additives, prescribed or over-the-counter medications, and drugs of abuse.
通过胎粪分析检测新生儿孕期非法药物及其他外源性物质的暴露情况。
收集98例新生儿的胎粪，采用高效液相色谱法和气相色谱/质谱法分析其中的非法药物及其他外源性物质。
81例（82.7%）婴儿的外源性物质检测呈阳性，每个婴儿体内存在1至9种药物。这些药物包括局部麻醉药（30%），如利多卡因和甲哌卡因；食品添加剂（25%），如生育酚（丁基化羟基甲苯）；非法药物（11%），尤其是可卡因和吗啡；镇痛药（10%），如哌替啶；以及较少见（<10%）的其他药物，如抗组胺药、抗抑郁药、肾上腺素能药物、抗惊厥药、止咳药、兴奋药、催眠镇静药和强心药。
我们证明新生儿大量暴露于外源性物质，包括食品添加剂、处方药或非处方药以及滥用药物。
