Gencoglu Esra Arzu, Dursun Dilek, Akova Yonca A, Cengiz Fethi, Yalcin Hulya, Koyuncu Aynur
Department of Nuclear Medicine, Baskent University Medical Faculty, Ankara, Turkey.
Ann Nucl Med. 2005 Oct;19(7):581-7. doi: 10.1007/BF02985051.
The aim of this study was to evaluate the tear clearance in patients with dry eye syndrome using quantitative lacrimal scintigraphy.
We investigated 21 patients (42 eyes; 18 women, 3 men; mean age, 63.19 +/- 13.33 years) with dry eye syndrome. Additionally, for the sake of comparison, 12 normal subjects of the same age group (24 eyes; 10 women, 2 men; mean age, 68.25 +/- 2.63 years) were included. Lacrimal scintigraphy, Schirmer-1 test, BUT, and rose bengal ocular surface vital staining were performed in these cases.
According to the results of lacrimal scintigraphy, the mean value of T 1/2 was 4.16 +/- 1.22 minutes and the mean value of RI was 14.15% +/- 2.30% in normal subjects. However, in patients with dry eye syndrome, these values were 20.59 +/- 1.97 minutes and 55.64% +/- 6.90%, respectively. Consistent with the results of ophthalmologic tests, the mean Schirmer-1 value was 12.46 +/- 2.10 mm, the mean value of BUT was 14.36 +/- 3.40 seconds, and the mean staining value of the rose bengal was 1.98 +/- 0.80 in normal subjects, whereas these values were 1.36 +/- 0.49 mm, 5.46 +/- 1.33 seconds, 6.62 +/- 0.86, respectively, in patients with dry eye syndrome. When we compared the results of lacrimal scintigraphy and the results of ophthalmologic tests, an inverse correlation was noted between both the T1/2 and RI values and both the Schirmer-1 and BUT values in all subjects (p < 0.001). However, there was a greater positive correlation between the rose bengal ocular surface staining value and both the T1/2 and RI values in all cases (p < 0.001).
In the current study, it was concluded that although the lacrimal drainage system was normal, tear clearance was significantly delayed in dry eye patients. With this study, we have shown that quantitative lacrimal scintigraphy, which is an objective, practical, and noninvasive method, appears to be useful for the assessment of the tear clearance in patients with dry eye syndrome.
本研究旨在通过定量泪腺闪烁显像评估干眼症患者的泪液清除情况。
我们调查了21例（42只眼；18名女性，3名男性；平均年龄63.19±13.33岁）干眼症患者。此外，为作比较，纳入了12名同年龄组的正常受试者（24只眼；10名女性，2名男性；平均年龄68.25±2.63岁）。对这些病例进行了泪腺闪烁显像、Schirmer - 1试验、泪膜破裂时间（BUT）以及孟加拉玫瑰红眼表活体染色检查。
根据泪腺闪烁显像结果，正常受试者的T 1/2平均值为4.16±1.22分钟，RI平均值为l4.15%±2.30%。然而，干眼症患者的这些值分别为20.59±1.97分钟和55.64%±6.90%。与眼科检查结果一致，正常受试者的Schirmer - 1平均值为12.46±2.10毫米，BUT平均值为14.36±3.40秒，孟加拉玫瑰红染色平均值为1.98±0.80，而干眼症患者的这些值分别为1.36±0.49毫米、5.46±1.33秒、6.62±0.86。当我们比较泪腺闪烁显像结果与眼科检查结果时，发现所有受试者中T1/2和RI值与Schirmer - 1和BUT值之间均呈负相关（p < 0.001）。然而，在所有病例中，孟加拉玫瑰红眼表染色值与T1/2和RI值之间均呈更强的正相关（p < 0.001）。
在本研究中，得出的结论是，尽管泪液引流系统正常，但干眼症患者的泪液清除明显延迟。通过本研究，我们表明定量泪腺闪烁显像作为一种客观、实用且无创的方法，似乎对评估干眼症患者的泪液清除情况有用。
Zotero 插件