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Effect of carotid artery ligation on regional cerebral blood flow in normotensive and spontaneously hypertensive rats.

作者信息

Choki J I, Yamaguchi T, Takeya Y, Morotomi Y, Omae T

出版信息

Stroke. 1977 May-Jun;8(3):374-9. doi: 10.1161/01.str.8.3.374.

DOI:10.1161/01.str.8.3.374
PMID:16364
Abstract

Regional cerebral blood flow (rCBF) was measured in normotensive rate (NTR) and spontaneously hypertensive rats (SHR), in a lightly anesthetized state and with control of PaCO2 by artificial ventilation. Without carotid artery ligation, NTR and SHR showed almost identical rCBF values and distribution, despite significantly elevated levels of blood pressure in SHR. Bilateral carotid artery ligation, however, caused much more pronounced decreases of rCBF (ischemia) in SHR than NTR, in regions supplied by the carotid artery. The reduction of rCBF in SHR was rather homogenous and symmetrical. Mechanisms causing the differences between NTR and SHR are discussed.

摘要

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