Wachtmeister L, Algvere P, Gjötterberg M
Department of Ophthalmology, Karolinska Institute, S:t Eriks Eye Hospital, Stockholm, Sweden.
Acta Ophthalmol (Copenh). 1992 Jun;70(3):389-94. doi: 10.1111/j.1755-3768.1992.tb08585.x.
This is a retrospective study of the benefit of transconjunctival cryotherapy for retinopathy of prematurity (ROP) in 43 eyes of 22 infants (birth weight 716-1675 g) from July 1985 to January 1988. Nine eyes were treated at ROP stage 4A (early), 14 eyes at stage 3 plus disease, and 20 eyes at stage 3. Cryotherapy was applied to the retinal avascular zone. In 13 eyes the ridge of extraretinal fibrovascular proliferation was also treated. Two eyes with peripheral exudative retinal detachment in two quadrants had additional treatment of the area of elevated retina. Reexamination was performed at the age of 26 to 52 months (average 38 months). Regression of the ROP was found in all eyes. Seven eyes showed a lateral traction of the temporal vascular arcades, six of these eyes had a slight macular ectopia. None of the eyes progressed to stage 4B or 5. Visual acuity was 6/60 or better. Twelve children (60%) achieved 6/18 or better and 5 (25%) 6/9 or more. Our data indicate that cryotherapy for ROP grade 3 and early stage 4A prevents the progression to advanced stages. The results also imply a functional benefit of cryotreatment in infants with progressive severe ROP.
这是一项回顾性研究，研究对象为1985年7月至1988年1月期间22例婴儿（出生体重716 - 1675克）的43只眼睛，探讨经结膜冷冻疗法治疗早产儿视网膜病变（ROP）的益处。9只眼睛在ROP 4A期（早期）接受治疗，14只眼睛在3期加病变阶段接受治疗，20只眼睛在3期接受治疗。冷冻疗法应用于视网膜无血管区。13只眼睛的视网膜外纤维血管增殖嵴也接受了治疗。两只出现两个象限周边渗出性视网膜脱离的眼睛，对视网膜隆起区域进行了额外治疗。在26至52个月龄（平均38个月）时进行复查。所有眼睛的ROP均出现消退。7只眼睛显示颞侧血管弓有侧向牵拉，其中6只眼睛有轻微黄斑异位。没有眼睛进展到4B期或5期。视力为6/60或更好。12名儿童（60%）达到6/18或更好，5名儿童（25%）达到6/9或更高。我们的数据表明，对3级和4A早期ROP进行冷冻疗法可防止病情进展到晚期。结果还表明，冷冻治疗对患有进行性严重ROP的婴儿有功能益处。
