在早产儿视网膜病变冷冻治疗试验中，对患有阈值早产儿视网膜病变的眼睛采用双弧视野计测量视野。早产儿视网膜病变冷冻治疗协作组。

Visual fields measured with double-arc perimetry in eyes with threshold retinopathy of prematurity from the cryotherapy for retinopathy of prematurity trial. The CRYO-Retinopathy of Prematurity Cooperative Group.

作者信息

Quinn G E, Dobson V, Hardy R J, Tung B, Phelps D L, Palmer E A

机构信息

Division of Pediatric Ophthalmology, Children's Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania, USA.

出版信息

Ophthalmology. 1996 Sep;103(9):1432-7. doi: 10.1016/s0161-6420(96)30487-9.

DOI:10.1016/s0161-6420(96)30487-9

PMID:8841302

Abstract

PURPOSE

To measure monocular visual field extent in very-low birth weight children in whom severe (threshold) acute-phase retinopathy of prematurity (ROP) developed in one or both eyes, and who had random assignment of eyes to cryotherapy or no cryotherapy. A control group of very-low birth weight children in whom ROP did not develop also was tested.

METHODS

There were 78 children in the severe ROP group from 5 of 23 centers in the randomized trial of cryotherapy for ROP (CRYO-ROP). The comparison cohort consisted of 75 study participants in whom ROP did not develop. All subjects had birth weights of less than 1251 g. At the 5 1/2-year study examination, visual field size was measured using double-arc kinetic perimetry. Testers were masked to treatment status of each eye. Four meridia were tested: superotemporal (ST), inferotemporal (IT), inferonasal (IN), and superonasal (SN). Target size was 6 degrees.

RESULTS

When blind eyes were assigned a score of 0 degree, the no-ROP, treated, and control eyes had an average visual field extent of 62 degrees, 35 degrees, 27 degrees at ST; 73 degrees, 42 degrees, 35 degrees at IT; 51 degrees, 30 degrees, 21 degrees IN; and 50 degrees, 26 degrees, 22 degrees at SN, respectively. Among 25 children who had bilateral threshold ROP and measurable fields in each eye, values for treated and control eyes were 59 versus 62 at ST, 69 versus 80 at IT, 44 versus 49 at IN, and 41 versus 48 at SN, respectively.

CONCLUSIONS

Overall, visual fields in eyes that reached threshold ROP were smaller than those of eyes that did not develop ROP. When only pairs of sighted eyes were considered, visual fields in the treated eyes were 6.4 degrees smaller than those of control eyes. Therefore, it appears that a small loss of peripheral field occurs when cryotherapy prevents the development of retinal detachment.

摘要

目的

测量双眼或单眼发生重度（阈值期）早产儿急性视网膜病变（ROP）且随机分配至接受冷冻疗法或不接受冷冻疗法的极低出生体重儿的单眼视野范围。还对一组未发生ROP的极低出生体重儿进行了测试。

方法

在ROP冷冻疗法随机试验（CRYO-ROP）中，来自23个中心中的5个中心的78名儿童纳入重度ROP组。比较队列包括75名未发生ROP的研究参与者。所有受试者出生体重均低于1251g。在5岁半的研究检查中，使用双弧动态视野计测量视野大小。检查者对每只眼睛的治疗状态不知情。测试了四个子午线：颞上（ST）、颞下（IT）、鼻下（IN）和鼻上（SN）。目标大小为6度。

结果

当将盲眼评分为0度时，未发生ROP的眼睛、接受治疗的眼睛和对照组眼睛在ST处的平均视野范围分别为62度、35度、27度；在IT处分别为73度、42度、35度；在IN处分别为51度、30度、21度；在SN处分别为50度、26度、22度。在25名双眼阈值期ROP且每只眼睛视野可测量的儿童中，接受治疗的眼睛和对照组眼睛在ST处的值分别为59度和62度，在IT处分别为69度和80度，在IN处分别为44度和49度，在SN处分别为41度和48度。