van der Eijk A A, de Man R A, Niesters H G M, Schalm S W, Zaaijer H L
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.
J Viral Hepat. 2006 Jan;13(1):2-4. doi: 10.1111/j.1365-2893.2005.00644.x.
Different guidelines exist for the management of hepatitis B virus (HBV)-infected health care workers (HCWs). Various HBV DNA levels are used as a cutoff level to determine whether an HBV-infected HCW is allowed to perform exposure-prone procedures (EPPs) or not. In this paper we discuss the factors that determine HBV DNA levels and the implications of different HBV DNA cutoff levels for EPP performing HCWs. If the level of HBV DNA in the serum of HCWs is used to determine acceptability for the conduct of EPPs, it is necessary to take into account the variability in time of HBV DNA levels in HBV carriers and the reliability and reproducibility of the molecular diagnostic test involved. The issue of standardization has to be addressed, before a universal, maximum level of viraemia for EPP performing HCWs can be introduced.
对于乙肝病毒（HBV）感染医护人员（HCWs）的管理存在不同的指导方针。各种HBV DNA水平被用作临界值，以确定HBV感染的医护人员是否被允许进行易发生暴露的操作（EPPs）。在本文中，我们讨论了决定HBV DNA水平的因素以及不同HBV DNA临界值对进行EPPs的医护人员的影响。如果用医护人员血清中的HBV DNA水平来确定进行EPPs的可接受性，就有必要考虑HBV携带者HBV DNA水平随时间的变化以及所涉及分子诊断检测的可靠性和可重复性。在引入针对进行EPPs的医护人员的普遍、最大病毒血症水平之前，必须解决标准化问题。
