Opriş Daniela, Iosif Cristina-Ileana, Predeţeanu Denisa
"Carol Davila" University of Medicine and Pharmacy, Department of Rheumatology and Internal Medicine, "St. Maria" Hospital, Bucharest, Romania.
Rom J Intern Med. 2004;42(4):715-23.
Sjögren's Syndrome (SS) is one of the most frequent autoimmune disorders, which affects approximately 1% of the population. It occurs in patients of all ages, but especially females during the fourth and fifth decades of life with a female/male ratio of 9:1. The main target of this disease are the exocrine glands that are infiltrated progressively by lymphocytes and finally destroyed, leading to decreased exocrine secretion. Thus primary SS is usually defined as xerophtalmia (dry eye) and xerostomia (dry mouth) accompanied in 60% of cases by parotid swelling [1]. The most serious complication of Sjögren's Syndrome is the high risk of the occurrence of non-Hodgkin's Lymphoma.
干燥综合征（SS）是最常见的自身免疫性疾病之一，约影响1%的人口。它可发生于各年龄段患者，但在40至50岁的女性中尤为常见，男女比例为9:1。这种疾病的主要靶器官是外分泌腺，淋巴细胞会逐渐浸润并最终破坏这些腺体，导致外分泌功能下降。因此，原发性干燥综合征通常被定义为干眼症和口干症，60%的病例伴有腮腺肿大[1]。干燥综合征最严重的并发症是发生非霍奇金淋巴瘤的高风险。
