Nagai K
Department of Internal Medicine, Niigata prefectural Central Hospital.
Nihon Rinsho. 1995 Oct;53(10):2574-9.
Sjögren's syndrome (SS) is characterized by an increased risk of development of a non-Hodgkin's lymphoma (NHL). In this paper, the clinical, histological and molecular biological topics, with a brief account of two cases of NHL, in SS are discussed. Low grade NHL, typically monocytoid B cell lymphoma related to mucosa associated lymphoid tissue (MALT) lymphoma, is the topic of NHL in SS. B cell clonal expansion has been detected by DNA analysis of immunoglobulin gene in non-lymphoma patients, as well as, in NHL patients in SS. Molecular biological analysis, especially detection of fusion gene of IgH and bcl-2, t(14;18), using PCR method, can help to detect early onset of NHL in SS. A better understanding of NHL in SS is needed to develop a co-operative research of large mass study.
干燥综合征（SS）的特征是发生非霍奇金淋巴瘤（NHL）的风险增加。本文讨论了SS中NHL的临床、组织学和分子生物学主题，并简要介绍了两例NHL病例。低度NHL，通常是与黏膜相关淋巴组织（MALT）淋巴瘤相关的单核细胞样B细胞淋巴瘤，是SS中NHL的主题。通过免疫球蛋白基因的DNA分析，在非淋巴瘤患者以及SS中的NHL患者中均检测到B细胞克隆性扩增。分子生物学分析，尤其是使用PCR方法检测IgH和bcl-2的融合基因t(14;18)，有助于检测SS中NHL的早期发病。需要更好地了解SS中的NHL，以开展大规模合作研究。
