Schoeman J, Steyn P S, Odendaal H J, Grové D
Department of Obstetrics and Gynaecology, Tygerberg Hospital, University of Stellenbosch, South Africa.
J Obstet Gynaecol. 2005 Nov;25(8):751-3. doi: 10.1080/01443610500314660.
This study was conducted as part of a double-blind randomised placebo-controlled trial, the aim of which was to determine whether vitamin C could reduce the recurrence risk of pre-term labour. In this study, women with a history of pre-term labour in a preceding pregnancy were randomised to receive either 250 mg vitamin C or a matching placebo twice daily until 34 weeks' gestation. They attended a dedicated pre-term labour clinic every 2 weeks. All women were screened for bacterial vaginosis (BV) at each visit. It was first determined that vitamin C did not have any effect on the presence of BV. Women who were diagnosed with BV before 20 weeks' gestation were at higher risk of delivering pre-term than those who developed BV after 20 weeks.
本研究是一项双盲随机安慰剂对照试验的一部分，其目的是确定维生素C是否可以降低早产的复发风险。在本研究中，有前次妊娠早产史的女性被随机分为两组，一组每天两次服用250毫克维生素C，另一组服用匹配的安慰剂，直至妊娠34周。她们每2周前往一个专门的早产诊所就诊。每次就诊时对所有女性进行细菌性阴道病（BV）筛查。首先确定维生素C对BV的存在没有任何影响。妊娠20周前被诊断为BV的女性比20周后患BV的女性早产风险更高。
