精液接触与细菌性阴道病发病之间的关联。
Association between semen exposure and incident bacterial vaginosis.
作者信息
Gallo Maria F, Warner Lee, King Caroline C, Sobel Jack D, Klein Robert S, Cu-Uvin Susan, Rompalo Anne M, Jamieson Denise J
机构信息
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
出版信息
Infect Dis Obstet Gynecol. 2011;2011:842652. doi: 10.1155/2011/842652. Epub 2011 Dec 8.
OBJECTIVE. To identify correlates of incident bacterial vaginosis (BV) diagnosed with Nugent scoring among high-risk women. STUDY DESIGN. We conducted both cohort and case-crossover analyses, stratified by HIV infection status, based on 871 HIV-infected and 439 HIV-uninfected participants in the HIV Epidemiology Research Study, conducted in 4 US sites in 1993-2000. RESULTS. BV incidence was 21% and 19% among HIV-infected and -uninfected women, respectively. Fewer correlates of BV were found with case-crossover than with cohort design. Reporting frequent coitus (regardless of consistency of condom use) was correlated with BV in cohort analyses but not in case-crossover analyses. The sole correlate of BV in both types of analyses was the detection of spermatozoa on Gram stain, which is a marker of semen exposure. CONCLUSION. The inconsistent association between condom use and BV in prior studies could be from reporting bias. We found evidence of a relationship between semen exposure and incident BV.
目的。确定高危女性中经 Nugent 评分诊断的细菌性阴道病（BV）发病的相关因素。研究设计。我们基于1993年至2000年在美国4个地点进行的HIV流行病学研究中的871名HIV感染参与者和439名未感染HIV的参与者，按HIV感染状况进行分层，开展了队列研究和病例交叉分析。结果。HIV感染女性和未感染女性的BV发病率分别为21%和19%。与队列设计相比，病例交叉分析中发现的BV相关因素较少。在队列分析中，报告频繁性交（无论避孕套使用的一致性如何）与BV相关，但在病例交叉分析中则不然。两种分析中BV的唯一相关因素是革兰氏染色上检测到精子，这是精液暴露的一个标志。结论。先前研究中避孕套使用与BV之间不一致的关联可能源于报告偏倚。我们发现了精液暴露与BV发病之间存在关联的证据。
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