创伤弧菌wbpP基因的鉴定及其毒力作用评估。
Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence.
作者信息
Park Na Young, Lee Jeong Hyun, Kim Myung Won, Jeong Hee Gon, Lee Byung Cheol, Kim Tae Sung, Choi Sang Ho
机构信息
Department of Food Science and Technology, School of Agricultural Biotechnology, Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, South Korea.
出版信息
Infect Immun. 2006 Jan;74(1):721-8. doi: 10.1128/IAI.74.1.721-728.2006.
Abstract
A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C(4) epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its phenotype changes, demonstrated that WbpP is essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.
摘要
从创伤弧菌中鉴定并克隆了一个编码假定的UDP-N-乙酰-D-葡糖胺C(4) 差向异构酶的wbpP基因。通过构建同基因突变体并评估其表型变化来评估wbpP基因的功能，结果表明WbpP在创伤弧菌的致病机制和荚膜多糖生物合成中均至关重要。
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